Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (12): 51-61.doi: 10.6040/j.issn.1671-7554.0.2023.0654

• The innovation and challenge of artificial intelligence in medical imaging-Clinical Research • Previous Articles    

Differentiation of benign and malignant skin focal protuberant nodules using microscope high-resolution MRI

JIN Xinjuan1, CAI Daxing2, FAN Jinlei1, DENG Zhanhao3, LI Nan2, YU Dexin1, LI Anning1   

  1. 1. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Imaging, Yantaishan Hospital, Yantai 264001, Shandong, China
  • Published:2024-01-11

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Abstract: Objective To explore the value of microscope high-resolution magnetic resonance imaging(MHR-MRI)in the differentiation of benign and malignant skin focal protuberant nodules. Methods A total of 45 patients with skin focal protuberant nodules admitted to Qilu Hospital of Shandong University during April 2020 and April 2023 and examined with preoperative MHR-MRI were prospectively analyzed. Based on pathological results, they were divided into benign group(n=19)and malignant group(n=26). The MHR-MRI characteristics of the lesions in the two groups were assessed. Differences between the benign and malignant groups, and among basal-cell carcinoma, protuberant skin fibrosarcoma and squamous cell carcinoma were compared. The sensitivity, specificity, Youden index and the area under the operating characteristic curve(AUC)and diagnostic efficiency of MHR-MRI were calculated. Results Lesions in the malignant group were more commonly characterized by sharp-angle-wedge sign(P<0.001), involvement of the epidermis and dermis(P<0.001), unclear boundaries(P=0.003), and the presence of surrounding vessels(P=0.003). The Youden index for a combined imaging parameters(sharp-angle-wedge sign, invasion of the epidermis and dermis, poorly defined borders, high signal intensity on T2WI, and combination of peripheral vessels)was 0.909(sensitivity 0.962, specificity 0.947)with an AUC of 0.995. The basal-cell carcinoma and protuberant skin fibrosarcoma were more often characterized by a wide base of the focus than the squamous cell carcinoma on MHR-MRI(P=0.021). The protuberant skin fibrosarcoma and squamous cell carcinoma were more often associated with sharp-angle-wedge sign than basal-cell carcinoma(P=0.001). Conclusion MHR-MRI is helpful in the differentiation of benign and malignant skin focal protuberant nodules and common malignant tumors.

Key words: Skin focal protuberant nodules, Microscope high-resolution magnetic resonance imaging, Benign and malignant, Differential diagnosis

CLC Number: 

  • R751
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