Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (10): 52-59.doi: 10.6040/j.issn.1671-7554.0.2019.873

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Safety of human assisted reproductive technology offspring

ZHANG Yingchun   

  1. Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University;
    Jinan Central Hospital Affiliated to Shandong First Medical University;
    Jinan Central Hospital, Jinan 250013, Shandong, China
  • Published:2022-09-27

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Abstract: With the maturation of assisted reproductive technology(ART), it has become a reliable means for infertile patients to overcome disease and obtain offspring. The effects of a variety of clinical and laboratory interventions in ART process, including in vitro fertilization(IVF), intracytoplasmic sperm injection(ICSI), preimplantation genetic diagnosis(PGD), embryo cryopreservation and freeze-thaw embryo resuscitation, on the safety of ART offspring have become the focus of reproductive medicine research. Present studies have shown that the health status of ART conceived offspring is similar to that of children conceived naturally, and ART is relatively safe. However, influenced by the age of ART offspring and the sample size, those studies only reported the data on the early follow-up of ART offspring after birth. There is no authoritative study to reveal the long-term health outcomes of ART offspring after adulthood, and whether these findings are associated with ART indications, causes of infertility, maternal age, genetic factors, IVF, and adverse perinatal outcomes related to IVF. This article reviews the safety of offspring following ART, and discusses topics on ART and birth defects, ART and preterm birth, ART and low birth weight infants, ART offspring growth and development assessment, and mental health of ART offspring, to provide a basis for the safe and effective application of human ART.

Key words: Assisted reproductive technology, In vitro fertilization, Intracytoplasmic sperm injection, Offspring, Safety

CLC Number: 

  • R711.75
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