Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (12): 39-46.doi: 10.6040/j.issn.1671-7554.0.2017.640

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Tracheobronchial amyloidosis: a report of 3 cases and literature review

ZHUANG Maisong1,2, WAN Yunyan1, LIN Dianjie1   

  1. 1. Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. First Department of Internal Medicine, Leling Peoples Hospital, Leling 253600, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the clinical and imaging manifestations, differential diagnosis and treatment of tracheobronchial amyloidosis. Methods The clinical data of 3 cases of tracheobronchial amyloidosis were retrospectively analyzed, and relevant literature was reviewed. Results Tracheobronchial amyloidosis exhibited no specific clinical or imaging manifestations. The main clinical symptoms included cough, chest distress, dyspnea, hemoptysis, and so on. The imaging manifestations included calcification(which was specific), thickening of wall, and narrowing of the lumen. In enhanced scanning, strengthened lesions could be observed. Clinical misdiagnosis and missed diagnosis often occurred due to localized tracheobronchial amyloidosis. Diffused lesions with hilar lymph node enlargement, calcification, and pulmonary nodular or patchy high-density shadow were often misdiagnosed as bronchial asthma, tuberculosis, chronic bronchitis and other diseases. Conclusion Tracheobronchial amyloidosis is a rare disease with no specific symptoms. Misdiagnosis and missed diagnosis frequently occur due to insufficient clinical and imaging understanding of the disease. Comprehensive analysis of the imaging manifestations and clinical characteristics, together with bronchoscopy and pathological examination, can help avoid possible misdiagnosis.

Key words: Tracheal bronchus, Amyloidosis, Misdiagnosis

CLC Number: 

  • R562
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