Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (9): 27-33.doi: 10.6040/j.issn.1671-7554.0.2020.0552

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Association of serum leptin with induced sputum eosinophils in 92 asthmatic patients

LIU Xiaofei1*, LIANG Ying2*, ZHANG Congxi2, WANG Juan2, PAN Yun1, XU Jiawei1, CHANG Chun2, DONG Liang1   

  1. 1. Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Pulmonary and Critical Care Medicine, Peking University, Third Hospital, Beijing 100191, China
  • Online:2020-09-10 Published:2020-08-30

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Abstract: Objective To determine whether serum leptin is related to airway and blood eosinophils in patients with asthma. Methods A cross-sectional study was conducted in 124 subjects, 92 of whom suffered from asthma including 46 overweight and 46 non-overweight and 32 of whom were healthy controls. Serum leptin levels were measured in all subjects, and induced sputum eosinophil and neutrophil percentages were determined in 57 asthmatic subjects. The differences among the three groups were evaluated by non-parametric test, correlation analysis and ordinal Logistic regression. Results Compared with healthy contrls, the serum leptin levels in asthmatic patients had no statistical difference. Overweight asthmatic subjects had significantly higher leptin levels than non-overweight asthmatic subjects, 17.7(11.1, 27.4)vs 10.2(7.8, 14.9)ng/mL, z=3.577, P<0.001. In subjects with asthma, leptin levels were positively correlated to the percentage of induced sputum eosinophils(r=0.285, P=0.031), but were not related to the percentage of induced sputum neutrophils and blood eosinophils. After adjustment for blood eosinophil level, serum IgE level, allergic rhinitis and usage of inhaled corticosteroids, multivariate ordinal Logistic regression analysis showed that serum leptin levels remained independently and positively related to the percentage of induced sputum eosinophils(OR=1.091, 95%CI:1.004-1.186, P=0.039). The correlation between serum leptin level and induced sputum eosinophils was statistically significant in non-overweight asthmatic subjects(r=0.496, P=0.005), while it was not statistically significant in overweight asthmatic subjects(r=0.094, P=0.640). Conclusion Compared with non-overweight asthmatic patients, serum leptin levels are significantly elevated in overweight asthmatic patients. Serum leptin is positively correlated to increased airway eosinophils in asthmatic patients.

Key words: Asthma, Leptin,, Eosinophil, Body mass index

CLC Number: 

  • R562.2
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