Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 113-118.doi: 10.6040/j.issn.1671-7554.0.2021.0254

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Evaluation of the efficacy of different regimens for early triple negative breast cancer based on the inverse probability of treatment weighting method

WANG Zhe1, LIU Yujie1, MAO Qian1, GUAN Peixia1, BAO Qihan1, LI Chengsheng1, QIAO Xiaowei1, PAN Qingzhong2, WANG Suzhen1   

  1. 1. Division of Biostatistics;
    2. Division of Mathematics, School of Public Health, Weifang Medical University, Weifang 261053, Shandong, China
  • Published:2021-09-16

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Abstract: Objective To evaluate the efficacy of breast conserving surgery with postoperative radiotherapy and mastectomy for patients with early triple negative breast cancer based on inverse probability of treatment weighting(IPTW)method. Methods We extracted the data related to patients diagnosed with T1-2N0M0 triple negative breast cancer from the SEER database during 2010 and 2015, calculated the inverse probability weights by estimating the propensity index through the generalized boosted model(GBM), and analyzed the effects of two local treatment modalities on the survival rate of patients with early triple negative breast cancer after weighting the balanced intergroup covariates. Results After IPTW, the covariates between groups reached complete equilibrium, and log-rank test showed that the overall survival(OS)was better in the breast conserving with postoperative radiotherapy group than in the mastectomy group(P<0.001). The multifactorial Cox regression analysis showed that the breast conserving surgery with postoperative radiotherapy remained to be prognostic beneficial compared to mastectomy(HR=0.74, 95%CI=0.65-0.84, P<0.001). Conclusion Breast conserving surgery with postoperative radiotherapy is more effective than mastectomy in patients with T1-2N0M0 triple negative breast cancer.

Key words: T1-2N0M0 triple negative breast cancer, Inverse probability of treatment weighting method, Breast conserving surgery with postoperative radiotherapy, Mastectomy, Efficiency evaluation

CLC Number: 

  • R181
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