Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (5): 96-103.doi: 10.6040/j.issn.1671-7554.0.2021.0120

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Two cases of anti-Ma2 antibody positive encephalitis in children and literature review

ZHAO Yongheng1,2, GAO Liang1,2, LI Baomin1   

  1. 1. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-06-01

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Abstract: Objective To screen the antibodies in 2 children with suspected autoimmune encephalitis, in order to explore the etiology, make a diagnosis, deepen the understanding of clinical manifestations, and guide the treatment. Methods Both children had clinical manifestations like general weakness with personality change, and convulsions with speech and motor disorders. Antibody screening was performed, and relevant literature was reviewed. Results Anti-Ma2 antibody serum antibodies were detected with Western blotting, and the patients were diagnosed as anti-Ma2 antibody positive encephalitis. The clinical features of 30 cases at home and abroad were compared and analyzed to deepen the understanding of the clinical manifestations. Conclusion Anti-Ma2 antibody positive encephalitis is caused by Anti-Ma2 antibody, and its clinical manifestations are varied. Antibody screening is beneficial to improve the diagnosis rate of this rare disease. Immunotherapy has good clinical efficacy.

Key words: Anti-MA2-associated encephalitis, Paraneoplastic syndrome, Autoimmune Encephalitis, Limbic encephalitis, Anti-neuronal cell antibodies

CLC Number: 

  • R725.9
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