Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (8): 101-106.doi: 10.6040/j.issn.1671-7554.0.2020.673

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Correlation of fat distribution with metabolic syndrome and glucose metabolism in 52 obese patients

HU Yanwen1, WANG Zhiyuan1, YU Wanjiang2, ZHAO Huichen1, HAN Heli2, XU Zhipeng2, MA Hong3, ZHANG Yuchao1, LIU Yuantao1   

  1. 1. Department of Endocrinology;
    2. Department of Radiology;
    3. Department of Health Care, Qingdao Municipal Hospital Affiliated to Medical School of Qingdao University, Qingdao 266011, Shandong, China
  • Published:2020-08-07

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Abstract: Objective To investigate the effects of fat distribution measured by quantitative-computed tomography(Q-CT)on metabolic syndrome(MS)and glucose metabolism in obese people. Methods Totally 52 patients with body mass index(BMI)≥28 were collected and divided into two groups: obesity with MS group(OB-MS group, n=32)and obesity without MS group(OB-NMS group, n=20). According to the results of 75g oral glucose tolerance test(OGTT), the subjects were divided into three groups: obesity with normal glucose tolerance group(OB-NGT group, n=17), impaired glucose tolerance group(OB-IGT group, n=15), and obesity with diabetes mellitus group(OB-DM group, n=20). The adipose tissue area and visceral fat area of lumbar vertebras 2, 3, 4 and 5, the muscle and fat area of bilateral psoas major and back muscles, and the percentages of liver fat and pancreatic fat were quantitatively determined with spiral CT. Meanwhile, various metabolic and biochemical indexes were detected and compared. Results OB-MS group had significantly larger visceral fat area(t=3.37)and higher percentage of pancreatic fat(t=2.05)than OB-NMS group. There were statistically significant differences in visceral fat area(F=7.63), percentage of liver fat(F=5.93)and percentage of pancreatic head fat(F=3.70)among the three groups with different glucose tolerance(P<0.05). OB-IGT and OB-DM groups had larger visceral fat area than OB-NGT group, and OB-DM group had greater percentages of liver fat and pancreatic head fat than OB-NGT group(P<0.05). Multiple linear regression results showed that after age and insulin resistance index were adjusted, visceral fat area(SB=-0.83, P=0.02)and percentage of pancreatic head fat(SB=-0.51, P=0.02)were negatively correlated with modified β-cell function index(MBCI). Conclusion The accumulation of visceral fat is an important factor leading to metabolic syndrome, while visceral fat, liver fat and pancreatic head fat are important risk factors leading to abnormal glucose metabolism in obese people. These results provide clinical indicators for the early identification of metabolic syndrome and diabetes in obese patients.

Key words: Obesity, Fat distribution, Metabolic syndrome, Abnormal glucose metabolism

CLC Number: 

  • R589
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