Abstract:

Objective   To study the effect of Tongxinluo capsules on treating diabetic nephropathy through the observation on the change of cystatin C(Cys-C). Methods   Sixty patients with early diabetic nephropathy were divided into the treatment group and the control group by the random number table method. Two groups were given medical nutrition therapy guide,  the application of hypoglycemic drugs to keep blood glucose under control and angiotensin converting enzyme inhibitors( ACEI) or angiotensin Ⅱ receptor blockers(ARB) to control blood pressure. On the basis of blood glucose and blood pressure target, Tongxinluo capsules were added into the treatment group. Before and after the treatment, the fasting blood glucose (FBG), serum creatinine (Scr), urinary albumin excretion rate (UAER), C reaction protein(CRP), and Cys-C were detected. Two groups were followed up for 12 weeks.  Results   Scr, UAER, CRP and Cys-C in two groups improved after the treatment, the treatment group took action faster and the effect of reducing UAER and Cys-C was better compared with the control group (P<0.05). Conclusion   Tongxinluo Capsules could improve renal microcirculation, reduce Cys-C, UAER, and delay the progress of renal damage in the treatment of early diabetic nephropathy.

Key words: Diabetic nephropathies； Tongxinluo capsules； Cystatin C