JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (3): 52-57.

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Effects of potassium iodate and bisphenol A on the proliferation of  thyroid carcinoma cells

LI Ya-nan1,  JIANG Ling1，  HU Xiu-hui1,  ZHANG Xiao-li1,  LI jie2   

  1. 1. Department of Endocrinology,  Qilu Hospital; 2. School of Public Health，
    Shandong University, Jinan 250012, China
  • Received:2012-11-07 Online:2013-03-10 Published:2013-03-10

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Abstract:

Objective   To observe the effects of potassium iodate and bisphenol A(BPA)on proliferation of thyroid carcinoma cells BHP10-3. Methods   10-3~10-10mol/L potassium iodate,  10-3~10-10mol/L bisphenol A and 10-7mol/L potassium iodate +10-8mol/L bisphenol A were added to the culture of BHP10-3 cells. Cell proliferation activity was examined by CCK-8 colorimetric assays,  and the cell cycles of the stimulated cells were analyzed by flow cytometer. The expression of Cyclin D1 protein was observed by western-blot,  and the expression of cyclinD1 mRNA was observed by RT-PCR. Results   Compared with the control group,  the absorbance of the potassium iodate group,  the BPA group and the potassium iodate+BPA group was higher (P<0.05), the proportion of cells in the G0-G1 phase decreased and proportion of cells in the S phase increased significantly (P<0.05), the expression levels of Cyclin D1 protein and mRNA were up-regulated significantly(P<0.05). Conclusion   The potassium iodate and BPA can promote the proliferation of thyroid papillary carcinoma cells in a certain concentration range.

Key words: Potassium iodiate; Bisphenol A; Thyroid papillary carcinoma; Cell proliferation

CLC Number: 

  • R587.1
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