Abstract:

Objective   To investigate the correlations between plasma homocysteine (Hcy) and hydrogen sulfide (H2S) levels and parameters of cerebral circulation dynamics in H type hypertension patients. Methods   104 patients were graded in H type hypertension group and hypertension group according to the level of plasma Hcy with 32 normal controls as the control group. The levels of plasma Hcy and H2S were measured by specific protein instrument and sulfur sensitive electrode. The parameters of cerebral circulation dynamics were detected by cerebral circulation dynamics detector. The levels of plasma folic acid and vitamin B12 were measured by auto DELFIA analyzer. Results   Compared with those of the controls and the hypertension group, the levels of plasma H2S, folic acid and vitamin B12 significant decreased in the H type hypertension group（P<0.05）, and the parameters of cerebral circulation dynamics had significant differences in the experiment group（P<0.001）. The level of plasma Hcy in the H type hypertension group had significantly nagative correlations with H2S, folic acid, vitamin B12, Vmean and Qmean (P<0.05).But it had significantly positive correlations with Rv, Zc and DR (P<0.05). The level of plasma H2S in the experimental group had significantly positive correlations with Qmean (P<0.05) and nagative correlations with Rv (P<0.05). Multiple linear regression analysis revealed a significant and independent association of Qmean with the increasing level of plasma Hcy, as was the association of Rv with the decreasing level of plasma H2S. The increasing level of plasma Hcy was an independent risk factor for the decreasing cerebral blood flow, and the decreasing level of plasma H2S was an independent risk factor for the increasing cerebral vascular resistance. Conclusion   Brain vascular physiology function was affected by the levels of plasma Hcy and H2S, which can cause changes of brain hemodynamics in H type hypertension.

Key words: Homocysteine; Hydrogen sulfide; Cerebrovascular hemodynamic; H type hypertension