Abstract:

Objective   To investigate the clinical value of the 5-FU sustained-release particles implanted through puncturing along the cardiac tangent direction for malignant pericardial effusion. Methods   81 patients with malignant pericardial effusion were treated by pericardiocentesis guided by ultrasound and 5-FU palliative particles were implanted into the pericardial cavity. The puncturing path was along the cardiac tangent direction. Ultrasound examinations were used every week after the treatment. The efficacy was evaluated four weeks after the treatment. The 45 patients treated by pericardial catheter drainage and intracavitary chemotherapy at the same period were served as controls. Results   The puncturing success rate was 100% in the 81 cases. Ultrasound reviews showed that complete remission occurred in 71，partial remission in 8, and no response in 2 cases four weeks after the treatment. The total remission rate was 97.53%, which was significantly higher than that in the control group(77.78%, P<0.01). Conclusion   It is a new ideal method to treat malignant pericardial effusion to implant 5-FU sustained-release particles through puncturing along the cardiac tangent direction for its high safety and efficacy and less adverse reactions.

Key words: Malignant cardiac effusion；  Ultrasonic interventional therapy； Pericardiocentesis； 5-FU palliative particles； Cardiac tangent direction