Abstract:

Objective   To investigate the difference of OSM expression between OA and the normal synovial membrane,and to discuss its function in the pathogenesis of knee osteoarthritis. Method   OSM expression was concurrently detected in synovial fluid samples from 33 patients with severe OA,10 patients with slight OA and 8 patients with normal disciform meniscus. We performed quantitative real-time PCR to determine all the genual synovium OSM gene expression levels. The distribution of OSM in all genual synovium was detected by immunohistochemical technology. Results    OSM was found in all patients′ synovial fluid.The expression level of OSM had a positive correlation with the severity of OA(P<0.05). There was no significant difference in expression of OSM between patients with slight OA and patients with normal disciform meniscus(P>0.05). Conclusion    OA synovial cells may have a higher level of OSM, which is related to the course of disease. OSM plays an important role in the pathogenesis process of osteoarthritis.

Key words: Osteoarthritis; Synovium; Oncostatin M； Knee joint