Abstract:

Objective   To study expression of vascular endothelial growth factor-c(VEGF-C) in hearts and lungs after subarachnoid hemorrhage(SAH) and to evaluate the protection of interferon-β(INF-β). Methods   The rat SAH model was established. The rats were randomly divided into the control group, the sham operation group, the SAH group with therapy and the SAH group without therapy. Expressions of VEGF-C in the hearts and lungs were detected. Results   VEGF-C expressions in hearts and lungs in the SAH group with therapy and the SAH group without therapy were higher than the sham operation group. VEGF-C expression in hearts and lungs in the SAH group without therapy was lower than the SAH group with therapy. Conclusion   SAH leads to cardiopulmonary ischemia through systemic inflammatory response. The INF-β can protect the organs by restraining the systemic inflammatory response.

Key words: Subarachnoid hemorrhage; Vascular endothelial growth factor-c; Interferonbeta; Rats