Abstract:

Objective   To investigate clinical characteristics and associated cardiovascular risk factors in prehypertensive patients with impaired glucose regulation(IGR). Methods   2158 residents aged 35-75 years old were enrolled by the cross-sectional and cluster sampling methods from 4 cities in Shandong, of which 865 subjects were prehypertensive. All the subjects were divided into three groups: the simple prehypertention group (groupⅠ, n=510) , the prehypertension with impaired glucose regulation group ( groupⅡ, n=278) and the prehypertension with diabetes group(group Ⅲ, n=77). The clinical characteristics and associated cardiovascular risk factors were compared among the threegroups. The risk factors of hyperglycemia were analyzed by binary logistic regression analysis. Results   The prevalence of IGR was 32.1% in prehypertensive population. The values of age, BMI, waist circumference, CHOL, TG and LDL-C in group Ⅱwere higher compared with groupⅠ(P<0.01). Age, WHR and TG in group Ⅲ showed a higher level compared with groups Ⅰand Ⅱ(P<0.05 or P<0.01). The values of waist circumference, CHOL, LDL-C in group II were obviously higher compared with group Ⅰ(P<0.01). The values of age, WHR and TG in group Ⅲ were obviously higher than those in group Ⅰand Ⅱ(P<0.05 or P<0.01). The values of waist circumference, CHOL and LDL-C in group Ⅲ were higher than those in group Ⅰ(P＜0.01). The value of HDL-C in the group Ⅲwas lower compared with groups I and II(P<0.05). The detection rates of obesity and hyperlipidemia were higher in groupⅡand groupⅢ(P<0.05). Patients in groupⅡand group Ⅲ were more likely to have 2 or more cardiovascular risk factors than group Ⅰ(P<0.05 or P<0.01). Age(OR=1.04, 95%CI: 1.02  1.05), BMI(OR=1.05, 95%CI: 1.01-1.10) and LDL-C(OR=1.22, 95%CI:1.02-1.46) proved to be the independent predictors for the impaired glucose regulation(all P<0.05 or P<0.01). Conclusion   Prehypertension with impaired glucose regulation is frequently accompanied with obesity and hyperlipidemia. Prehypertensive patients with higher BMI, LDL-C, or older age were more likely to have impaired glucose regulation.

Key words: Prehypertension； Diabetes mellitus； Impaired glucose regulation；  Cardiovascular disease； Risk factors