JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (8): 88-.

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Risk factors of acute hepatitis B complicated with
serious hyperbilirubinemia

SUN Chao1,2, XIE Shuang-shuang2， XIAO Di2, LIU Cai-xia1,2, YU Jin-hong2, LIU Li2, LI Qiang2   

  1. 1. School of Medicine, Shandong University, Jinan 250012, China;
    2. Second Department of Jinan Infectious Disease Hospital， Jinan 250021， China
  • Received:2012-06-06 Online:2012-08-10 Published:2012-08-10

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Abstract:

Objective   To investigate the prevalence and risk factors of acute hepatitis B complicated with serious hyperbilirubinemia(serum total bilirubin level > 171μmol/L）. Methods   Demographic data,biochemical parameters, serology and virology arguments of 618 patients with acute hepatitis B in Jinan Infectious Disease Hospital were analyzed. Results   Elevated bilirubin levels were detected in 549 patients(88.5%), among which bilirubin levels in 202 cases (32.7%)were higher than 171μmol/L. Univariate analysis showed that old patients with alcohol abuse, fever, fatigue and bad appetite were more likely to suffer from serious hyperbilirubinemia(P＜0.001). Multivariate logistic regression analysis showed that old age, alcohol abuse, fever, fatigue and bad appetite were independent risk factors for serious hyperbilirubinemia in acute hepatitis B. Conclusion   Old age, alcohol abuse, fever, fatigue and bad appetite are independent risk factors for serious hyperbilirubinemia in acute hepatitis B.

Key words: Hepatitis B, Acute; Hyperbilirubinemia; Risk factors；Clinical characteristics；Severity

CLC Number: 

  • R512.6
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