Abstract:

Objective    To investigate  expression of cyclin D1 protein in endometrial carcinoma and to evaluate its clinical significance. Methods   Expression of cyclin D1 protein was determined by using the immunohistochemical method in 20 normal endometria, 38 endometrial atypical hyperplasias and 126 endometrial carcinoms. The correlations of cyclin D1 expression with clinicopathological parameters and overall survival in endometrial carcinoma were studied. Results   Immunohistochemistry showed that normal endometria and endometrial atypical hyperplasias were negligible for cyclin D1 expression. Expression of cyclin D1 in normal endometria and endometrial atypical hyperplasias was significantly less than that in endometrial carcinomas (P<0.001). Cyclin D1 expression was significantly associated with clinicopathological parameters, including surgical stage(P＝0.006), histological grade(P＝0.010), lymph node metastasis(P＝0.008) and histological type(P＝0.020), but not with depth of myometrial invasion, positive peritoneal cytology and age(P>0.05). Patients with cyclin D1 expression had significant poorer overall survival compared with the patients without  expression (P=0.017). Conclusions   Cyclin D1 overexpression may be involved in  tumorigenesis and development of human endometrial carcinoma, which could be used as a predictor of the prognosis for the patients with endometrial carcinoma.

Key words: Endometrial neoplasms； Immunohistochemistry； Cyclin D1； Prognosis