Abstract:

Objective   To detect expressions of G3BP and Stathmin in Sinonasal inverted papilloma（NIP）and explore their roles in the development of NIP as well as their interrelationships. Method   The immunohistochemical (PV-9000 two-step method) method was used to analyze protein expressions of G3BP and Stathmin in paraffin embedded tissues from 34 cases of sinonasal inverted papilloma, At the same time,  expressions of these two proteins was also measured in 20 cases of  inferior nasal concha mucosa and 12 cases of nasal squamous cell carcinoma as controls. SPSS13.0 was applied to determine the differences and correlation in the NIP. Results   Positive expression rates of Stathmin protein and G3BP protein in sinonasal inverted papilloma were 52.9％ and 73.5％, which were significantly higher than those in the inferior nasal concha mucosa ( 0％and 0％;P<0.05). Expression rates of Stathmin protein and G3BP protein in nasal squamous cell carcinoma were 75％ and 83.3％, which were higher than those in the sinonasal inverted papilloma. Significant differences were found in expressions of Stathmin (P<0.05), but not   - G3BP (P> 0.05). Stathmin  was positively related to expression of G3BP（rs＞0，P＜0.001）. Conclusion   Stathmin protein and G3BP protein were highly expressed in sinonasal inverted papilloma. The result indicates that they may be associated with the recur rence and invasiveness of sinonasal inverted papilloma. Because Stathmin  was positively related to expression of G3BP, joint detection of Stathmin and G3BP may be useful in the diagnosis and prognosis of cancer.

Key words: Sinonasal inverted papilloma；G3BP；Stathmin ；Immunohistochemistry；NIP