Abstract:

Objective     To observe the short-term curative efficacy of transfusing autogeneic cytokine-killer cells(CIK) cultured in vitro on patients with gynecological malignant carcinoma. Methods     Blood samples isolated from 8 patients with gynecological malignant carcinoma were induced in vitro to obtain CIK, which were then transfused into the patients. The short-term curative efficacy was evaluated by comparison of the immunological function, level of CA125 in serum, Karnofsky performance score(KPS) and change of clinical symptoms before and two months after transfusion. Results      After transfusion, both the ratio of CD4+/CD8+ and percentage of CD3-CD16+CD56+ in peripheral blood were increased(P<0.05),while the percentage of CD4+CD25+ was decreased(P<0.05). The level of CA125 in serum was decreased in 5 cases. The KPS was increased in one case. Clinical symptoms were ameliorated in 5 cases. At the same time, no adverse reaction was observed. Conclusion     Transfusing autogeneic CIK has some short-term curative efficacy on gynecological malignant carcinoma.

Key words: Cytokine-induced killers cells; Gynecological malignant carcinoma; Immunotherapy