Abstract:

Objective     To investigated interference of low molecular weight heparin(LMWH) on non-alcoholic steatohepatitis caused by high-fat diet in the rat and study its mechanism. Methods     Male Sprague-Dawley rats（n=40） were randomly divided into the control group（n=10）and the model group（n=10）: the model group was given a highfat diet for 8 weeks;  the low dosage treatment group（n=10） and high dosage treatment group（n=10）: one received low doses of LMWH ［50IU/(kg·d）］ and the other received 200IU/(kg·d） for 2 weeks, after 8 weeks of high-fat diet.   Results    Compared with the model group, a high dose of LMWH［200IU/(kg.d)］ significantly inhibited chronic inflammation and attenuated lipid deposits in the liver, while a low dose of LMWH was not significant.  Conclusion     LMWH has an excellent therapeutic effect on non-alcoholic fatty liver disease (NAFLD) by inhibiting chronic inflammation and attenuating lipid deposits in the liver, which is closely related to the dosage. Its mechanism may be that LMWH regulates the level of blood fat and decreases the level of TNFα in the serum.

Key words: Non-alcoholic steatohepatitis； Low molecular weight heparin；Triglyceride；Cholesterol；Tumor necrosis factor-α；Rats, Sprague-Dawley