JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (9): 122-124.

• Articles • Previous Articles     Next Articles

Effect of miniinvasive hematoma aspiration on the content of glial

fibrillary acidic protein in patients with cerebral hemorrhage

CUI Yuanxiao1, CHI Zhaofu1，　ZHANG Qinghua2, YU Zhaoang2, QI Qinde3    

  1. 1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Department of Neurology,  Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 
    3. Department of Neurology, Laiwu People′s Hospital, Laiwu 271100, Shandong, China
  • Received:2009-06-25 Published:2009-09-16

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Abstract:

To study the concentration of serum glial fibrillary acidic protein（GFAP）in patients with hypertensive cerebral hemorrhage after minimally invasive surgery (MIS). MethodsBlood samples were obtained on day 1 (before the operation in the MIS  group), 3, 7, and 14 after the onset in 74 patients with MIS and 80 patients with non minimally invasive surgery (NMIS), and 60 normal controls(the NC group). Serum GFAP was detected by enzyme linked immunosorbent assay(ELISA). ResultsThe content of serum GFAP in the NMIS group significantly increased on day1, rose to a climax on day7, and then decreased, but was still significantly higher than that in the control group. Compared with the NMIS group, the level of serum GFAP in the MIS group significantly decreased on day 7 and 14. GFAP  had correlations with nerve function deficiency score (NDS). ConclusionsMiniinvasive hematoma aspiration can decrease the serum level of  GFAP in patients with cerebral hemorrhage. Serum GFAP is a potential marker for prognosis and outcome in patients with nonminimally invasive surgery.

Key words: Intracranial hemorrhage, hypertensive; Glial fibrillary acidic protein; Punctures

CLC Number: 

  • R743.34
[1] SHANG Xiao1, CUI Yuan-xiao1, LIU Xiao-yu1, FENG Xiao-ya2. Experimental study of human umbilical cord mesenchymal stem cells combined with minimal hematoma aspiration in the therapy of rats with intracerebral hemorrhage [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(10): 10-14.
[2] CUI Yuan-xiao1， TANG Qian-qian1， GUO Zhang-yu1, SHANG Xiao1, ZHANG Qing-hua1， FENG Xiao-ya2. Experimental research of apoptosis in rat tissue cells surrounding
intracerebral hemorrhage after minimal hematoma aspiration [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 36-.
[3] TANG Qian-qian1， YUAN Qian2, CUI Yuan-xiao1， ZHANG Qing-hua1， GUO Zhang-yu1. Effects of heat shock protein 70 on expressions of the Bcl-2 and Bax proteins in nerve cells of rats with intracerebral hemorrhage [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 40-.
[4] TIAN Min, YUAN Qian, CUI Yuan-xiao, ZHANG Qing-hua, TANG Qian-qian . Dynamic fluctuation of fibrinolytic activity in patients withmini-invasive hematoma aspiration [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(10): 73-76.
[5] YU Zhaoang, CUI Yuanxiao, ZHANG Qinghua, TIAN Min, TANG Qianqian. Dynamic observation of serum interleukin6 and matrix metalloproteinase-9 in patients with cerebral hemorrhage after minimally invasive hematoma aspiration [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 105-.
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