基因重组人生长激素（rh-GH）对大鼠牙周组织受正畸力后改建影响的实验研究

山东大学学报(医学版)

基因重组人生长激素（rh-GH）对大鼠牙周组织受正畸力后改建影响的实验研究

黄艳¹，王旭霞¹，张文娟²，刘超¹，张君¹

1. 山东大学口腔医学院正畸科，山东济南 250012；2. 山东中医药大学附属医院口腔科，山东济南 250012

收稿日期:2007-03-09 修回日期:1900-01-01 出版日期:2007-09-24 发布日期:2007-09-24
通讯作者: 张君

Effects of rh-GH on experimental remodeling of powered periodontal tissues of rats

HUANG Yan¹，WANG Xu-xia¹，ZHANG Wen-juan²，LIU Chao¹，ZHANG Jun¹

1.Department of Orthodontics, School of Stomatology, Shandong University；2.Department of Stomatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Received:2007-03-09 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
Contact: ZHANG Jun

摘要/Abstract

摘要： 目的：了解生长激素缺乏时大鼠正畸牙周组织的改建特征，探讨rh-GH对成年大鼠牙周组织受正畸力后改建的影响。方法：选用30只7周龄雌性SPF级Wistar大鼠，随机均分为对照组、摘除卵巢组（NS组）、rh-GH组。手术方法建立成年及正畸牙移动动物模型，测量3组大鼠牙齿移动距离并进行牙齿牙周联合切片的组织学观察。结果：无论是2周处死的大鼠还是4周处死的大鼠，第一磨牙移动距离均为NS组最大、rh-GH组次之、对照组最小，各组间差异有统计学意义，P＜0.05；rh-GH能减轻正畸治疗带来的牙周膜损伤和炎症，抑制牙槽骨、牙骨质乃至牙本质的异常吸收，利于骨改建过程平衡的恢复。结论：rh-GH可明显抑制成年大鼠正畸牙齿的移动，利于成年大鼠牙周组织受正畸力后的改建及骨改建过程平衡的恢复。

Abstract: Objective: To investigate the effect of rh-GH on experimental remodeling of powered periodontal tissues during orthodontic tooth movement in adult rats. Methods: Thirty female 7 week old SPF Wister rats were randomly divided into three groups: the control group, the NS group, the rh-GH group. The orthodontic tooth movement models were established by operation. The distance of tooth movement was measured and the periodontal tissues were histologically studied. Results: The distance of tooth movement of the control group was the shortest, that of the NS group was the longest, and that of the rhGH groual was shorter than that of the NS group and longer than that of the control group in the three groups. All the results had statistical significances. rh-GH significantly improved the periodontal membrane condition and may promote alveolar bone forming and inhibit bone resorption. Conclusion: rh-GH may slow the tooth movement of adult rats and improve the remodeling of powered periodontal tissues.

Key words: rh-GH, Adult orthodontics, Periodontal tissue, Remodeling

黄艳,王旭霞,张文娟,刘超,张君 . 基因重组人生长激素（rh-GH）对大鼠牙周组织受正畸力后改建影响的实验研究[J]. 山东大学学报(医学版), 2007, 45(9): 899-902.

HUANG Yan,WANG Xu-xia,ZHANG Wen-juan,LIU Chao,ZHANG Jun. Effects of rh-GH on experimental remodeling of powered periodontal tissues of rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 899-902.

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