喷昔洛韦脂质体制备及质量控制

山东大学学报(医学版)

喷昔洛韦脂质体制备及质量控制

宋丽洁，王唯红，陆金萍

山东大学药学院药物分析室，山东济南 250012

收稿日期:2006-05-16 修回日期:1900-01-01 出版日期:2007-06-24 发布日期:2007-06-24
通讯作者: 王唯红

Preparation and quality control of penciclovir liposome

SONG Li-jie, WANG Wei-hong, LU Jin-ling

Institute of Pharmaceutical Analysis, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China

Received:2006-05-16 Revised:1900-01-01 Online:2007-06-24 Published:2007-06-24
Contact: WANG Wei-hong

摘要/Abstract

摘要： 目的：制备喷昔洛韦脂质体，并控制其质量。方法：以均匀设计优化工艺制得喷昔洛韦脂质体，透射电镜观察其形态，广角度激光光散射仪测定粒径，凝胶柱层析法结合系数倍率法测其包封率及渗漏率。结果：脂质体平均粒径426.8nm，平均包封率60.76％。结论：该脂质体制备工艺可行，检测方法可靠。

关键词: 脂质体, 质量控制 , 喷昔洛韦

Abstract: Objective： To study the preparation of penciclovir liposomes and its quality control. Methods： The optimum preparation technology was established by a uniform design. Negative staining and the laser scattering particle size distribution analyzer were used to study the structure and size of liposomes. A gel column and Kratio spectrophotometry were developed to determine the entrapment efficiency. Results： The average size of liposomes was 426.8nm. The entrapment efficiency was 60.76%. Conclusion： The preparation of penciclovir liposome is practicable and should be investigated further.

Key words: Penciclovir, Lliposome, Quality control

中图分类号:

R944

宋丽洁,王唯红,陆金萍. 喷昔洛韦脂质体制备及质量控制[J]. 山东大学学报(医学版), 2007, 45(6): 635-638.

SONG Li-jie,WANG Wei-hong,LU Jin-ling. Preparation and quality control of penciclovir liposome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(6): 635-638.

参考文献

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