绞窄性肠梗阻血清磷脂酶A2的变化

山东大学学报(医学版)

绞窄性肠梗阻血清磷脂酶A2的变化

陈江谊¹，刘钧澄²，马少锋¹，陈普祺¹

1. 广东省江门市中心医院小儿外科，广东江门 529030；2. 中山大学附属第一医院小儿外科，广东广州 510000

收稿日期:2006-03-16 修回日期:1900-01-01 出版日期:2007-06-24 发布日期:2007-06-24
通讯作者: 陈江谊

Evaluation of serum phospholipase A2 in patients with strangulated bowel obstruction

CHEN Jiang-yi¹，LIU Jun-cheng²，MA Shao-feng¹，CHEN Pu-qi¹

1.Department of Pediatris, Jiangmen Central Hospital；2.Department of Pediatris, First Affiliated of Sun Yat-sen University

Received:2006-03-16 Revised:1900-01-01 Online:2007-06-24 Published:2007-06-24
Contact: CHEN Jiang-yi

摘要/Abstract

摘要： 目的：探讨不同程度肠梗阻与血清磷脂酶A2(PLA2)激活间的关系。方法：采用ELISA法检测不同类型、不同阶段肠梗阻患者血清中PLA2的浓度，并经统计学分析两者之间的关系。结果：血清中PLA2浓度随着肠梗阻程度的增加而升高。肠梗阻患者血清中PLA2浓度明显高于对照组［(1.22±0.66)mg/L vs (0.17 ±0.02 )mg/L， t=9.05，P＜0.001］。绞窄性肠梗阻患者血清中PLA2浓度明显高于单纯性肠梗阻组［(1.72±0.36)mg/L vs (0.57±0.24)mg/L， t=17.89,P＜0.001］。在绞窄性肠梗阻组中，发生肠坏死患者血清中的PLA2浓度与肠缺血组比较，差异也有统计学意义［(1.96±0.14)mg/L vs (1.54±0.37)mg/L，t=5.16，P＜0.001］。结论：血清PLA2对早期判断是否出现绞窄性肠梗阻有积极的意义，可为早期手术治疗提供参考。

关键词: 肠梗阻 , 磷脂酶A2

Abstract: Objective： To explore the value of serum phospholipase A2(PLA2) in acute strangulated bowel obstruction. Methods： The serum PLA2 level was determined in different types of bowel obstruction, including strangulated obstruction, simple obstruction,torpid obstruction, and in controls by ELISA. Strangulated obstruction was subdivided into two groups: the ischemia group and the necrosis group. Their linear relations were statistical analyzed. Results： The mean serum concentration of PLA2 in the bowel obstruction group was significantly elevated compared with the healthy controls［(1.22±0.66) mg/L vs (0.17 ±0.02) mg/L］ (t=9.05,P＜0.001), the strangulated obstruction group was significantly higher than those of the simple obstruction group［(1.72±0.36) mg/L vs (0.57±0.24)mg/L (t=17.89,P＜0.001),　and the ischemia group was significantly higher than of the necrosis group［(1.96±0.14 )mg/L vs (1.54±0.37)mg/L (t=5.16，P＜0.001).　Conclusions： The serum PLA2 level correlates closely with the severity of obstruction. It has great value for early diagnosis of strangulated bowel obstruction and offers solid evidence for early treatment.

Key words: Phospholipase A2, Intestinal obstruction

中图分类号:

R737.9

陈江谊,刘钧澄,马少锋,陈普祺 . 绞窄性肠梗阻血清磷脂酶A2的变化[J]. 山东大学学报(医学版), 2007, 45(6): 613-615.

CHEN Jiang-yi,LIU Jun-cheng,MA Shao-feng,CHEN Pu-qi. Evaluation of serum phospholipase A2 in patients with strangulated bowel obstruction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(6): 613-615.

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