幽门螺杆菌感染与胃癌关系的Meta-analysis研究

山东大学学报(医学版)

幽门螺杆菌感染与胃癌关系的Meta-analysis研究

安宁¹,李登新²，陈彤³，张建业⁴

1. 济南市卫生局卫生监督所，山东济南 250011； 2. 潍坊市人民医院消化内科，山东潍坊 262200；3. 济南市中医医院针灸科，山东济南 250002； 4. 山东大学医学院免疫学教研室，山东济南 250012

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-04-24 发布日期:2007-04-24
通讯作者: 安宁

A Meta-analysis between the helicobacter pylori infection and gastric carcinoma

AN Ning¹, LI Deng-xin², CHEN Tong³, ZHANG Jian-ye⁴

1. Sanitation Supervision Center of Jinan Public Health Bureau;2. Department of Digest, Weifang People′s Hospital;3. Department of Acupuncture and Moxibustion, Jinan Hospital of Traditional Chinese Medicine;4. Department of Immunology, School of Medicine

Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
Contact: AN Ning

摘要/Abstract

摘要： 目的：探讨幽门螺杆菌（Hp）感染胃粘膜与胃癌的关系。方法：根据资料一致性检验结果，采用随机效应模型（D-L法）对检索到的国内23篇有关流行病学研究文献进行了综合定量分析。结果：Hp感染与胃癌的发生有明显的联系（OR=2.72，95％CI：1.91～3.87）；其中与胃非贲门部癌、腺癌的联系具有统计学意义，其合并OR（95%CI）依次为2.72（1.91～3.87）、3.94（2.41～6.42）；与胃贲门部癌及非腺癌的联系无统计学意义（OR=1.38，95%CI：0.91～2.08）、（OR=1.55，95%CI：0.99～2.44）。结论：Hp感染与胃癌的发生有联系。文中对该综合分析结果及可能出现的偏倚进行了讨论。

Abstract: Objective: To investigate the correlation between Helicobacter pylori infection and gastric carcinoma. Methods: According to the consistent of the test results, twenty-three articles of epidemiology referred were analyzed by the D-L method. Results: There was a significant correlation between gastric carcinoma and Helicobacter pylori infection(OR=2.72, 95％CI：1.91～3.87). There was a statistical significance between Helicobacter pylori infection with gland carcinoma and gastric non-cardia carcinoma(OR=2.72,3.94), and not a statistical significance between Helicobacter pylori infection with non-gland carcinoma and gastric cardia carcinoma(OR=1.55). Conclusion: There is significant correlation between gastric carcinoma and Helicobacter pylori infection.

Key words: Helicobacter, Pyloi, Cancer of stomach, Meta-analysis

中图分类号:

R181.2+3

安宁,李登新,陈彤,张建业 . 幽门螺杆菌感染与胃癌关系的Meta-analysis研究[J]. 山东大学学报(医学版), 2007, 45(4): 423-426.

AN Ning,LI Deng-xin,CHEN Tong,ZHANG Jian-ye. A Meta-analysis between the helicobacter pylori infection and gastric carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(4): 423-426.

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