D2-40标记的甲状腺乳头状癌中微淋巴管密度与淋巴结转移之间的关系

山东大学学报(医学版)

D2-40标记的甲状腺乳头状癌中微淋巴管密度与淋巴结转移之间的关系

刘红，张建平，赵著梅，王妍，刘文君，张泽立，李红

山东大学医学院病理学教研室，山东济南 250012

收稿日期:2006-11-10 修回日期:1900-01-01 出版日期:2007-03-24 发布日期:2007-03-24
通讯作者: 张建平

D2-40 positive micro-lymphatic vessel density in the thyroid papillary carcinoma correlate with lymphatic metastasis

LIU Hong， ZHANG Jian-ping， ZHAO Zhu-mei， WANG Yan， LIU Wen-jun， ZHANG Ze-li， LI Hong

Department of Pathology， School of Medicine， Shandong University， Jinan 250012， Shandong， China

Received:2006-11-10 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
Contact: ZHANG Jian-ping

摘要/Abstract

摘要： 目的：应用新型淋巴内皮标记物D2-40分析甲状腺乳头状癌及周围组织微淋巴管密度(MLVD)与淋巴结转移之间的关系。方法：应用免疫组织化学Envison法检测46例甲状腺乳头状癌和20例结节性甲状腺肿中D2-40和CD34的表达，分别计数MLVD和微血管密度(MVD)，分析其与甲状腺乳头状癌淋巴结转移之间的关系，同时与病变中MVD行对比观察。结果：91.3％甲状腺乳头状癌乳头轴心中的间质中无淋巴管。微淋巴管主要位于甲状腺乳头状癌周围结缔组织及被膜中。甲状腺乳头状癌周围结缔组织及被膜中的MLVD和MVD与淋巴结转移有密切关系，MLVD和MVD越高淋巴结转移率越高。同时甲状腺乳头淋巴管内的癌栓与淋巴结转移也显著相关（P＜0.001）。结论：甲状腺乳头状癌的转移过程与微淋巴管及微血管的形成有密切关系。干预肿瘤转移抑制血管生成的同时也需要抑制淋巴管生成。

Abstract: Objective: Specimens of papillary thyroid carcinoma and nodular goiter have been immunohistochemically studied by using a novel monoclonal antibody D2-40 which is specific against lymph epithelial cells in the detection of the newly formed micro-lymphatic vessel density（MLVD） in lesions in order to seek clues of papillary thyroid carcinoma and its well known ability to involve regional lymph nodes. Micro-vascular density（MVD）as the future of tumor angiogenesis was immunochemically compared by CD34. Methods: MLVD and MVD were determined by conventional HE staining and Envison immunohistochemistry using D2-40 and CD34 monoclonal antibodies in 46 specimens of papillary thyroid carcinoma and 20 of nodular goiter. Results: The micro-lymphatic vessel of papillary thyroid carcinoma in the peripheral zone of stroma appeared to be associated with the spread of tumors to regional lymph nodes. Conclusion: The metastasis process of thyroid papillary carcinoma is associated with the formation of the micro-lymphatic vessel and micrangium. The antimetastatic potential for targeting these lymphatics may be of potential therapeutic benefit in the future.

Key words: Thyroid neoplasms, Antigens, Lymphnode metastasis, Immunohistochemistry

中图分类号:

R736.1

刘红,张建平,赵著梅,王妍,刘文君,张泽立,李红. D2-40标记的甲状腺乳头状癌中微淋巴管密度与淋巴结转移之间的关系[J]. 山东大学学报(医学版), 2007, 45(3): 253-256.

LIU Hong,ZHANG Jian-ping,ZHAO Zhu-mei,WANG Yan,LIU Wen-jun,ZHANG Ze-li,LI Hong. D2-40 positive micro-lymphatic vessel density in the thyroid papillary carcinoma correlate with lymphatic metastasis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 253-256.

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