Abstract: Objective: To investigate the effect of dietary fat intake on human serum apolipoprotein(apo) AIV levels and further illustrate the regulation of food intake and bodyweight gain. Methods: This investigation was conducted in 389 subjects aged 770 years from Zibo and Jinan city in Shandong Province. The serum apoAIV concentrations were measured by enzymelinked immunosorbant assays (ELISA). Dietary intake was estimated from 3day food record. Statistical analyses were performed with SPSS 12.0. Results: Serum apoAIV levels were negatively correlated with dietary fat, fiber, carbohydrate, and protein intake（P<0.05）. Humans chronically consuming a highfat diet initially developed significantly lower serum apoAIV levels than those of a lowfat diet. Conclusion: A highfat diet intake is the primary factor to affect serum apoAIV levels.

Key words: Apolipoprotein AIV, Dietary fats, Obesity