Her-2/neu,Syndecan-1在胃癌中的表达及意义

山东大学学报(医学版)

Her-2/neu,Syndecan-1在胃癌中的表达及意义

王潍博¹,刘丰基²,崔言刚¹

1．山东省立医院化疗科，山东济南 250021； 2．潍坊市人民医院保健科，山东潍坊 261041

收稿日期:2005-09-14 修回日期:1900-01-01 出版日期:2006-09-24 发布日期:2006-09-24
通讯作者: 王潍博

WANG Wei-bo,LIU Ji-feng,CUI Yan-gang

Received:2005-09-14 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24
Contact: WANG Wei-bo

摘要/Abstract

摘要： 目的：检测胃癌组织中Her2/neu，Syndecan1表达情况，探讨二者在胃癌发生发展及侵袭、转移中的作用。方法：应用免疫组化SP法检测112例胃癌组织及40例正常胃粘膜中Her2/neu,Syndecan1表达。结果：① 112例胃癌组织和40例正常胃粘膜中Her2/neu阳性表达率分别为20.5％和5％，Syndecan1阳性表达率分别为46.4％和100.0％。胃癌组织Her2/neu阳性表达率显著高于正常胃粘膜阳性表达率（χ2=5.17,P＜0.05）,正常胃粘膜Syndecan1阳性表达率显著高于胃癌组织（χ2=20.80，P＜0.01）；② 胃癌组织 Her2/neu的表达与胃癌分化程度（χ2=4.82,P＜0.05），TNM分期（χ2=5.37,P＜0.05）、淋巴结转移多少（χ2=6.42,P＜0.05）及浆膜浸润（χ2=7.30,P＜0.01）均显著相关； ③　胃癌组织Syndecan1的表达与胃癌分化程度、淋巴结转移呈负相关（χ2=11.83,P＜0.01和χ2=13.74,P＜0.01）；④　胃癌组织中Her2/neu阳性表达与Syndecan1的阴性表达显著相关(χ2=14.25,P＜0.01)。结论：①　Her2/neu高表达显示胃癌恶性程度高、分期晚、预后不良；② Syndecan1属保护性因素，在恶性程度高、分期晚的患者中表达降低；③ Her2/neu阳性表达的胃癌组织中Syndecan1的表达降低。

Abstract: To study the effect of Her2/neu and Syndecan1 in gastric carcinoma. Methods: The expressions of Her2/neu and Syndecan1 were measured by using immunohistochemistry method in 112 patients with gastric cancer and 40 healthy controls. Results： ① Her2/neu was expressed in 20.5 % of the gastric cancer tissue and 5.0% of the healthy gastric mucosa (χ2＝5.17， P ＜ 0.05)， and Syndecan1 was expressed in 46.4% of the gastric cancer tissue and 100% of the healthy mucosa (χ2＝20.80，　P＜ 0.01)； ② the expression of Her2/neu was significantly correlated with the differentiation, lymph node metastasis and clinical stage (P＜0.05) and depth of invasion (P＜0.01); ③ the expression of Syndecan1 was significantly correlated with the differentiation and the lymph node metastasis (P＜ 0.01). Conclusion： ① The expression of Her2/neu is significantly correlated with the clinicopathological factors (P＜0.05) which suggests that Her2/neu is a risk factor for gastric cancer;　② the expression of Syndecan1 is significantly correlated with the differentiation and the lymph node metastasis, which suggests that Syndecan1 is a protective factor for gastric cancer;　 ③　the expression of Her2/neu in gastric cancer tissue is significantly correlated with that of Syndecan1.

Key words: Gastric neoplasms, Her2/neu, Syndecan1, Immunohistochemistry, Clinical grade, Tumor metastasis, Prognosis

王潍博,刘丰基,崔言刚 . Her-2/neu,Syndecan-1在胃癌中的表达及意义[J]. 山东大学学报(医学版), 2006, 44(9): 914-917.

WANG Wei-bo,LIU Ji-feng,CUI Yan-gang. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(9): 914-917.

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