阿奇霉素聚乳酸微球的制备及其体外释药特性的研究

山东大学学报(医学版)

阿奇霉素聚乳酸微球的制备及其体外释药特性的研究

韩永涛¹,黄桂华²,席延卫²,祝瑞红³

山东大学 1. 齐鲁医院药剂科； 2. 药学院药剂学教研室； 3. 药学院99级本科生, 山东济南 250012

收稿日期:2006-01-10 修回日期:1900-01-01 出版日期:2006-08-24 发布日期:2006-08-24
通讯作者: 韩永涛

HAN Yong-tao,HUANG Gui-hua2,XI Yan-wei,ZHU Rui-hong

1. Department of Pharmaceutics, Qilu Hospitial of Shandong University;2. Department of Pharmaceutics, School of Pharmacy, Shandong University;

Received:2006-01-10 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
Contact: HAN Yong-tao

摘要/Abstract

摘要： 以聚乳酸为载体材料制备阿奇霉素微球(AZMMS)并考察其体外释药特性。方法：采用乳化-溶剂挥发法制备AZMMS，并对其形态、粒径、包封率、结构和质量、体外释药特性等进行研究。结果：微球外观形态为类球形实体，粒径分布较均匀，平均粒径dav=(20.8±0.5)?μm，三批载药微球的包封率为(68.3±1.28)%；体外释药符合Higuchi方程，差示扫描热分析证明微球的形成。结论：本实验筛选的最佳处方工艺可制备性质优良的阿奇霉素肺靶向聚乳酸微球。

Abstract: To prepare microsphere containing Azithromycin（AZM） with polylactic acid, and investigate the characteristics of AZM microsphere (AZMMS)in vitro release. Methods: AZMMS was prepared by emulsion solutionevaporation, and its morphology and particle size were examined by light electron microscope.Entrapment ratio, structural properties, quality and the release of AZM in vitro were studied. Results: The AZMMS assumed spherical shape. Its distribution of particle diameter was even with an average particle size of(20.8±0.5)nm. The entrapment ratio was(68.3±1.29)%. The release of AZMMS in vitro conformed to Higuchi Equation.The formation of a new material phase was testified by differential scanning calorimetry(DSC). Conclusion: AZMMS is a good lungtargeting drug release system.

Key words: Azithromycin, Polylactic acid, Microsphere

韩永涛,黄桂华,席延卫,祝瑞红 . 阿奇霉素聚乳酸微球的制备及其体外释药特性的研究[J]. 山东大学学报(医学版), 2006, 44(8): 853-856.

HAN Yong-tao,HUANG Gui-hua,XI Yan-wei,ZHU Rui-hong. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(8): 853-856.

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