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IL-10在成人牙周炎炎症牙龈组织中的检测

程培红1,戚向敏2,孙善珍3   

  1. 山东大学 1.齐鲁医院口腔科;2.口腔医院牙周黏膜科;3.口腔医院病理科,山东 济南 250012
  • 收稿日期:2006-02-19 修回日期:1900-01-01 发布日期:2006-06-25
  • 通讯作者: 程培红

Expression of IL10 in gingival lesion in adult periodontitis

CHENG Pei-hong1,QI Xiang-min2,SUN Shan-zhen3   

  1. 1. Department of Oral Medicine, Qilu Hospital of Shandong University;2. Department of Periodontal Membrane, School of Stomatology, Shandong University;3. Department of Pathology, School of Stomatology, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-02-19 Revised:1900-01-01 Published:2006-06-25
  • Contact: CHENG Pei-hong

摘要: 目的:探讨白细胞介素10 (IL10)在成人牙周炎不同临床状态下牙龈组织中的表达。 方法: 采用免疫组织化学SABC法检测IL10在24例成人牙周炎(包括脓肿组12例和治疗组12例)、10例牙龈炎患者(牙龈炎组)和6例牙周健康者(对照组)牙龈组织中的表达。结果:脓肿组IL10的表达量低于对照组、牙龈炎组及治疗组(P<0.05、P<0.01、P<0.01),治疗组IL10的表达量高于对照组及牙龈炎组(P<0.01、P<0.01)。结论:牙周炎活动性病变IL10表达减少,牙周炎治疗后IL10表达增加,IL10在牙周组织的修复中发挥保护作用。

Abstract: To investigate the expression of IL10 in gingival tissues of various clinical stages in adult periodontitis. Methods: Immunohistochemistry SABC method was used to semiquantitatively measure the expression of IL10 in 24 adults with periodontits(12 in periodontal abscess group and 12 in treatment group), 10 patients with gingivitis and 6 healthy controls. Results: The quantity of IL10 was lower in abscess group than that in healthy controls, gingivitis and treatment group, respectively (P<0.05, P<0.01, P<0.01), and it was significantly higher in treatment group than that in healthy controls and gingivitis group (P<0.01, P<0.01). Conclusion: The expression of IL10 decreases in the activity of periodontitis, but increases after treatment, suggesting IL10 acts as a protective role in the restoration of periodontal tissues.

Key words: Interleukin10, Periodontitis, Adult, Gingiva, Tissues

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