IL-10在成人牙周炎炎症牙龈组织中的检测

IL-10在成人牙周炎炎症牙龈组织中的检测

Expression of IL10 in gingival lesion in adult periodontitis

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山东大学学报(医学版)

程培红¹,戚向敏²,孙善珍³

山东大学 1.齐鲁医院口腔科；2.口腔医院牙周黏膜科；3.口腔医院病理科，山东济南 250012

收稿日期:2006-02-19 修回日期:1900-01-01 发布日期:2006-06-25
通讯作者: 程培红

CHENG Pei-hong¹,QI Xiang-min²,SUN Shan-zhen³

1. Department of Oral Medicine, Qilu Hospital of Shandong University;2. Department of Periodontal Membrane, School of Stomatology, Shandong University;3. Department of Pathology, School of Stomatology, Shandong University, Jinan 250012, Shandong, China

Received:2006-02-19 Revised:1900-01-01 Published:2006-06-25
Contact: CHENG Pei-hong

摘要： 目的：探讨白细胞介素10 （IL10）在成人牙周炎不同临床状态下牙龈组织中的表达。方法：采用免疫组织化学SABC法检测IL10在24例成人牙周炎（包括脓肿组12例和治疗组12例）、10例牙龈炎患者（牙龈炎组）和6例牙周健康者（对照组）牙龈组织中的表达。结果：脓肿组IL10的表达量低于对照组、牙龈炎组及治疗组（P＜0.05、P＜0.01、P＜0.01），治疗组IL10的表达量高于对照组及牙龈炎组（P＜0.01、P＜0.01）。结论：牙周炎活动性病变IL10表达减少，牙周炎治疗后IL10表达增加，IL10在牙周组织的修复中发挥保护作用。

Abstract: To investigate the expression of IL10 in gingival tissues of various clinical stages in adult periodontitis. Methods: Immunohistochemistry SABC method was used to semiquantitatively measure the expression of IL10 in 24 adults with periodontits(12 in periodontal abscess group and 12 in treatment group), 10 patients with gingivitis and 6 healthy controls. Results: The quantity of IL10 was lower in abscess group than that in healthy controls, gingivitis and treatment group, respectively (P＜0.05, P＜0.01, P＜0.01), and it was significantly higher in treatment group than that in healthy controls and gingivitis group (P＜0.01, P＜0.01). Conclusion: The expression of IL10 decreases in the activity of periodontitis, but increases after treatment, suggesting IL10 acts as a protective role in the restoration of periodontal tissues.

Key words: Interleukin10, Periodontitis, Adult, Gingiva, Tissues

程培红,戚向敏,孙善珍 . IL-10在成人牙周炎炎症牙龈组织中的检测[J]. 山东大学学报(医学版), 2006, 44(6): 622-625.

CHENG Pei-hong,QI Xiang-min,SUN Shan-zhen. Expression of IL10 in gingival lesion in adult periodontitis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(6): 622-625.

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