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山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (3): 45-49.doi: 10.6040/j.issn.1671-7554.0.2015.887

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潺槁木姜子地上部位化学成分

徐有伟1,周洪雷1,任冬梅2,娄红祥2,沈涛2   

  1. 1.山东中医药大学药学院药物化学所, 山东 济南 250355;2.山东大学药学院生药学研究所 天然产物化学生物学教育部重点实验室, 山东 济南 250012
  • 收稿日期:2015-09-18 出版日期:2016-03-10 发布日期:2016-03-10
  • 通讯作者: 沈涛. E-mail:shentao@sdu.edu.cn E-mail:shentao@sdu.edu.cn
  • 基金资助:
    山东省自然科学基金(ZR2014HM019);山东大学青年学者未来计划(2015WLJH50)

Chemical constituents from the aerial parts of Litsea glutinosa(Lour.)C.B. Rob.

XU Youwei1, ZHOU Honglei1, REN Dongmei2, LOU Hongxiang2, SHEN Tao2   

  1. 1.Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China;
    2. Department of Pharmacognosy, School of Pharmaceutical Sciences, Shandong University, Key Lab of Chemical Biology Ministry of Education, Jinan 250012, Shandong, China
  • Received:2015-09-18 Online:2016-03-10 Published:2016-03-10

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摘要： 目的 对樟科木姜子属植物潺槁木姜子［Litsea glutinosa(Lour.)C.B. Rob.］地上部位的化学成分进行研究。 方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱等技术对潺槁木姜子的化学成分进行分离,并采用核磁共振波谱等技术确证化合物的结构。 结果 从潺槁木姜子95%乙醇提取物乙酸乙酯部分获得5个化合物,并鉴定为pubinernoid A(I)、吐叶醇(II)、滨藜叶分药花苷(III)、1,2-dihydro-6,8-dimethoxy-7-1-(3,5-dimethoxy-4-hydroxyphenyl)-N1,N2- bis-［2-(4-hydroxyphenyl)ethyl］-2,3-naphthalene dicarboxamide(IV)和胡萝卜苷(V)。 结论 化合物I~IV为首次从潺槁木姜子中分离得到,并且化合物I~III为首次从木姜子属植物中分离得到。

关键词: 潺槁木姜子, 化学成分, 结构鉴定

Abstract: Objective To study the chemical constituents from the aerial parts of Litsea glutinosa(Lour.)C.B. Rob. Methods The obtained compounds were isolated by different chromatographic methods, including silica gel, Sephadex LH-20 and high performance liquid chromatography, and then their structures were elucidated on the basis of spectroscopic analyses, particularly the nuclear magnetic resonance spectroscopy. Results Five compounds were isolated from the EtOAc partition of the 95% EtOH extract of the aerial parts of Litsea glutinosa, and their structures were identified as pubinernoid A(I), vomifoliol(II), atroside(III), 1,2-dihydro-6,8-dimethoxy-7-1-(3,5-dimethoxy-4-hydroxyphenyl)- N1,N2-bis-［2-(4-hydroxyphenyl)ethyl］-2,3-naphthalene dicarboxamide(IV), and daucosterol(V). Conclusion Compounds I-IV are isolated from Litsea glutinosa for the first time, and compounds I-III are obtained from the genus of Litsea for the first time.

Key words: Litsea glutinosa, Chemical constituents, Structure identification

中图分类号: 

  • R284.2
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