您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (3): 45-49.doi: 10.6040/j.issn.1671-7554.0.2015.887

• • 上一篇    下一篇

潺槁木姜子地上部位化学成分

徐有伟1,周洪雷1,任冬梅2,娄红祥2,沈涛2   

  1. 1.山东中医药大学药学院药物化学所, 山东 济南 250355;2.山东大学药学院生药学研究所 天然产物化学生物学教育部重点实验室, 山东 济南 250012
  • 收稿日期:2015-09-18 出版日期:2016-03-10 发布日期:2016-03-10
  • 通讯作者: 沈涛. E-mail:shentao@sdu.edu.cn E-mail:shentao@sdu.edu.cn
  • 基金资助:
    山东省自然科学基金(ZR2014HM019);山东大学青年学者未来计划(2015WLJH50)

Chemical constituents from the aerial parts of Litsea glutinosa(Lour.)C.B. Rob.

XU Youwei1, ZHOU Honglei1, REN Dongmei2, LOU Hongxiang2, SHEN Tao2   

  1. 1.Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China;
    2. Department of Pharmacognosy, School of Pharmaceutical Sciences, Shandong University, Key Lab of Chemical Biology Ministry of Education, Jinan 250012, Shandong, China
  • Received:2015-09-18 Online:2016-03-10 Published:2016-03-10

PDF (PC)

388

摘要： 目的 对樟科木姜子属植物潺槁木姜子［Litsea glutinosa(Lour.)C.B. Rob.］地上部位的化学成分进行研究。 方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱等技术对潺槁木姜子的化学成分进行分离,并采用核磁共振波谱等技术确证化合物的结构。 结果 从潺槁木姜子95%乙醇提取物乙酸乙酯部分获得5个化合物,并鉴定为pubinernoid A(I)、吐叶醇(II)、滨藜叶分药花苷(III)、1,2-dihydro-6,8-dimethoxy-7-1-(3,5-dimethoxy-4-hydroxyphenyl)-N1,N2- bis-［2-(4-hydroxyphenyl)ethyl］-2,3-naphthalene dicarboxamide(IV)和胡萝卜苷(V)。 结论 化合物I~IV为首次从潺槁木姜子中分离得到,并且化合物I~III为首次从木姜子属植物中分离得到。

关键词: 潺槁木姜子, 化学成分, 结构鉴定

Abstract: Objective To study the chemical constituents from the aerial parts of Litsea glutinosa(Lour.)C.B. Rob. Methods The obtained compounds were isolated by different chromatographic methods, including silica gel, Sephadex LH-20 and high performance liquid chromatography, and then their structures were elucidated on the basis of spectroscopic analyses, particularly the nuclear magnetic resonance spectroscopy. Results Five compounds were isolated from the EtOAc partition of the 95% EtOH extract of the aerial parts of Litsea glutinosa, and their structures were identified as pubinernoid A(I), vomifoliol(II), atroside(III), 1,2-dihydro-6,8-dimethoxy-7-1-(3,5-dimethoxy-4-hydroxyphenyl)- N1,N2-bis-［2-(4-hydroxyphenyl)ethyl］-2,3-naphthalene dicarboxamide(IV), and daucosterol(V). Conclusion Compounds I-IV are isolated from Litsea glutinosa for the first time, and compounds I-III are obtained from the genus of Litsea for the first time.

Key words: Litsea glutinosa, Chemical constituents, Structure identification

中图分类号: 

  • R284.2
[1] 国家中医药管理局《中华本草》编委会. 中华本草[M]. 上海: 上海科学技术出版社, 1999.
[2] 黄燮才, 周珍诚, 张骏. 广西民族药简编[M]. 南宁: 广西壮族自治区卫生局药品检验所, 1980.
[3] Kong DG, Zhao Y, Li GH, et al. The genus Litsea in traditional Chinese medicine: an ethnomedical, phytochemical and pharmacological review[J]. J Ethnopharmacol, 2015, 164: 256-264.
[4] 汪云松, 黄荣, 李良, 等. 潺槁木姜子中黄酮类成分研究[J]. 中草药, 2008, 39(10): 1466-1468. WANG Yunsong, HUANG Rong, LI Liang, et al. Flavonoids from Litsea glutinosa[J].Chin Tradit Herbal Drugs, 2008, 39(10): 1466-1468.
[5] Wang YS, Liao Z, Li Y, et al. A new megastigmane diglycoside from Litsea glutinosa( Lour. )C.B. Rob.[J]. J Braz Chem Soc, 2011, 22(11): 2234-2238.
[6] Pan JY, Zhang S, Wu J, et al. Litseaglutinan A and lignans from Litsea glutinosa[J]. Helv Chim Acta, 2010, 93(5): 951-957.
[7] Choudhury S, Singh R, Ghosh AC, et al. Litsea glutinosa(Lour.)C.B. Rob., a new source of essential oil from northeast India[J]. J Essent Oil Res, 1996, 8(5): 553-556.
[8] Yang JH, Li L, Wang YS, et al. Two new aporphine alkaloids from Litsea glutinosa[J]. Helv Chim Acta, 2005, 88(9): 2523-2526.
[9] Mandal S, Kumar C, Majumder A, et al. Antibacterial activity of Litsea glutinosa bark[J]. Fitoterapia, 2000, 71(4): 439-441.
[10] Devib P, Meera R. Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa[J]. J Pharm Sci Res, 2010, 2(3): 155-163.
[11] Das D, Maiti S, Maiti TK, et al. A new arabinoxylan from green leaves of Litsea glutinosa(Lauraeae): structural and biological studies[J]. Carbohydr Polym, 2013, 92(2): 1243-1248.
[12] Huang SX, Yang J, Xiao WL, et al. Three novel terpenoids from Schisandra pubescens var. pubinervis[J]. Helv Chim Acta, 2006, 89(6): 1169-1175.
[13] Siddiqui BS, Kardar MN, Ali ST, et al. Two new and a known compound from Lawsonia inermis[J]. Helv Chim Acta, 2003, 86(6): 2164-2169.
[14] Ali M, Saleem M, Erian A. A new acylated steroid glucoside from Perovskia atriplicifolia[J]. Fitoterapia, 2001, 72(6): 712-714.
[15] Yang Q, Ye G, Zhao WM. Chemical constituents of Commelina communis Linn.[J]. Biochem Syst Ecol, 2007, 35(9): 621-623.
[16] Wang L, Wang LN, Zhao Y, et al. Secondary metabolites from Marchantia paleacea calluses and their allelopathic effects on Arabidopsis seed growth[J]. Nat Prod Res, 2013, 27(3): 274-276.
[17] Wang L, Yang J, Chi YQ, et al. A new myrsinol-type diterpene polyester from Euphorbia dracunculoides Lam[J]. Nat Prod Res, 2015, 29(15): 1406-1413.
[18] 荣光庆, 耿长安, 马云保, 等. 合欢花乙酸乙酯部位化学成分研究[J]. 中国中药杂志, 2014, 39(10): 1845-1851. RONG Guangqing, GENG Changan, MA Yunbao, et al. Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin[J]. Chin J Chin Mater Med, 2014, 39(10): 1845-1851.
[19] 魏倩, 杨建波, 王爱国, 等. 茶芎地上部位化学成分研究[J]. 中草药, 2014, 45(14): 1980-1983. WEI Qian, YANG Jianbo, WANG Aiguo, et al. Chemical constituents from aerial parts of Ligusticum sinense cv. chaxiong[J]. Chin Tradit Herbal Drugs, 2014, 45(14): 1980-1983.
[20] 梁文娟, 马青云, 蒋合众, 等. 红毛丹果壳的化学成分研究[J]. 中草药, 2011, 42(7): 1271-1275. LIANG Wenjuan, MA Qingyun, JIANG Hezhong, et al. Chemical constituents from hulls of Nephelium lappaceum[J]. Chin Tradit Herbal Drugs, 2011, 42(7): 1271-1275.
[21] Hiermann A. The contents of sabal fruits and testing of their anti-inflammatory effect[J]. Arch Pharm(Weinheim), 1989, 322(2): 111-114.
[22] Sun J, Gu YF, Su XQ, et al. Anti-inflammatory lignanamides from the roots of Solanum melongena L.[J]. Fitoterapia, 2014, 98: 110-116.
[23] Pan PC, Cheng MJ, Peng CF, et al. Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity[J]. J Nat Prod, 2010, 73(5): 890-896.
[24] Agrawal N, Pareek D, Dobhal S, et al. Butanolides from Methanolic Extract of Litsea glutinosa[J]. Chem Biodivers, 2013, 10(3): 394-400.
[25] 覃文慧, 冯旭, 李耀华, 等. 广西山胶木树叶鲜、干品中挥发油成分的GC-MS 分析[J]. 安徽农业科学, 2012, 40(24): 12003-12004, 12084. QIN Wenhui, FENG Xu, LI Yaohua, et al. GC-MS analysis of the essential oils from fresh and dry leaves of Litsea glutinosa (Lour.)C. B. Rob.[J]. Journal of Anhui Agricultural Sciences, 2012, 40(24): 12003-12004, 12084.
[26] 周燕园. 水蒸气蒸馏与超临界CO2萃取香胶木叶挥发油化学成分的GC-MS分析[J]. 中国实验方剂学杂志, 2012, 18(2): 116-118. ZHOU Yanyuan. Chemical constituents in essential oil from Litsea glutinosa by steam distillation and SFE-CO2 by GC-MS[J]. Chin J Exp Tradit Med Form, 2012, 18(2): 116-118.
[1] 刘青, 商蒙蒙, 孙霄, 李杰, 杨杰, 时丹丹, 宁松. 泌尿系结石化学成分对超声声影强弱的影响[J]. 山东大学学报（医学版）, 2015, 53(9): 19-23.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发