茶苯海明口腔崩解片的药代动力学研究

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (Z1): 229-230.

茶苯海明口腔崩解片的药代动力学研究

徐亚军¹, 初海坤², 王暖凤¹, 李敏¹, 李梅¹, 王艳菊³

1. 大庆油田总医院药剂科, 黑龙江大庆, 163000;
2. 大庆油田总医院骨伤科, 黑龙江大庆, 163000;
3. 黑龙江省医院南岗分院体检科, 黑龙江哈尔滨 150036

收稿日期:2014-11-30 出版日期:2014-12-30 发布日期:2014-12-30

Study on pharmacokinetics of dimenhydrinate orally disintegrating tablets

XU Ya-jun¹, CHU Hai-kun², WANG Nuan-feng¹, LI Min¹, LI Mei¹, WANG Yan-ju³

1. Department of Pharmacy, Daqing 163000, Heilongjiong China;
2. Department of Orthopedics and Traumatology, Daqing Oilfield General Hospital, Daqing 163000, Heilongjiong China;
3. Department of Physical Examination, Heilongjiang Provincial Hospital Nangang Branch, Haerbin 150036, China

Received:2014-11-30 Online:2014-12-30 Published:2014-12-30

摘要/Abstract

摘要： 目的探讨茶苯海明口腔崩解片的药代动力学。方法选取参与受试的体检健康成年男性30例,随机分为2组,各15例,口腔崩解片组给予服用口腔崩解片,普通片组给予普通片。高效液相-紫外检测茶苯海明在血浆中浓度。结果口腔崩解片组达峰时间(Tpeak),吸收速率常数(Ka),峰浓度(Cmax),延滞时间(Lag time)及曲线下面积(AUC)与普通片比较差异有统计学意义(P<0.01)。以普通片为对照,口腔崩解片的相对生物利用度高达180.12%。结论口腔崩解片剂型能显著提高茶苯海明的生物利用度。

关键词: 茶苯海明, 口腔崩解片, 生物利用度

Abstract: Objective To investigate the pharmacokinetics of dimenhydrinate orally disintegrating tablets. Methods A total of 30 healthy participants were randomly divided into orally disintegrating tablets group (n=15) and normal tablets group (n=15). High performance liquid chromatography method was performed to detect the plasma concentration of dimenhydrinate. Results Time to peak(Tpeak), the Ka value, peak concentration(Cmax), lag time and area under cuive in disintegrating tablets group were different from those in normal tablet group (P<0.01). The relative bioavailability of disintegrating tablets against normal tablets was 180.12%. Conclusion The bioavailability of dimenhydrinate can be enhanced under a dosage form of orally disintegrating tablets.

Key words: Bioavailability, Dimenhydrinate, Orally disintegrating tablets

中图分类号:

R944.9

徐亚军, 初海坤, 王暖凤, 李敏, 李梅, 王艳菊. 茶苯海明口腔崩解片的药代动力学研究[J]. 山东大学学报（医学版）, 2014, 52(Z1): 229-230.

XU Ya-jun, CHU Hai-kun, WANG Nuan-feng, LI Min, LI Mei, WANG Yan-ju. Study on pharmacokinetics of dimenhydrinate orally disintegrating tablets[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(Z1): 229-230.

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