阿米替林治疗痛性糖尿病周围神经病变的临床研究

doi:10.6040/j.issn.1671-7554.0.2014.948

山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (5): 81-84.doi: 10.6040/j.issn.1671-7554.0.2014.948

阿米替林治疗痛性糖尿病周围神经病变的临床研究

孙卓浩¹, 刘妍², 周冬梅³, 李伟³

1. 徐州医学院, 江苏徐州 221002;
2. 枣庄市立第四医院影像科, 山东枣庄 277500;
3. 徐州医学院附属医院内分泌科, 江苏徐州 221000

收稿日期:2014-12-12 修回日期:2015-03-25 出版日期:2015-05-10 发布日期:2015-05-10
通讯作者: 李伟。E-mail:liwei.190@hotmail.com E-mail:liwei.190@hotmail.com

A clinic research of amitriptyline in treatment of painful diabetic peripheral neuropathy

SUN Zhuohao¹, LIU Yan², ZHOU Dongmei³, LI Wei³

1. Xuzhou Medical College, Xuzhou 221002, Jiangsu, China;
2. Department of Radiology, Zaozhuang Fourth Municipal Hospital, Zaozhuang 277500, Shandong, China;
3. Department of Endocrinology, the Affilicated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu, China

Received:2014-12-12 Revised:2015-03-25 Online:2015-05-10 Published:2015-05-10

摘要/Abstract

摘要： 目的研究阿米替林对痛性糖尿病周围神经病变(PDPN)的治疗效果。方法 104例糖尿病周围神经病变(DPN)患者随机分为治疗组(n=52)和对照组(n=52)。治疗组给予阿米替林、甲钴胺、依帕司他治疗;对照组仅予甲钴胺、依帕司他治疗。治疗12周,比较两组治疗前后神经传导速度、视觉模拟评分(VAS)的变化。结果与对照组相比,治疗组的神经传导速度更快,VAS降低,差异有统计学意义(P<0.05)。结论采用阿米替林治疗PDPN效果更佳。

关键词: 阿米替林, 糖尿病周围神经病变, 神经病理性疼痛

Abstract: Objective To observe the clinical effect of amitriptyline on the treatment of painful diabetic peripheral neuropathy (PDPN). Methods A total of 104 patients with diabetic peripheral neuropathy (DPN) were randomly divided into the case group (n=52) and control group (n=52). The case group was treated with amitriptyline, mecobalamine and epalrestat; while the control group was just treated with mecobalamine and epalrestat. The treatment lasted for 12 weeks. Nerve conduction velocity, visual analogue scale (VAS) of the two groups were compared before and after the treatment. Results Compared with the control group, the nerve conduction velocity of the case group was faster and VAS decreased (P<0.05). Conclusion The effect of using amitriptyline in treatment of PDPN is better.

Key words: Amitriptyline, Diabetic peripheral neuropathy, Neuropathy pain

中图分类号:

R589.1

孙卓浩, 刘妍, 周冬梅, 李伟. 阿米替林治疗痛性糖尿病周围神经病变的临床研究[J]. 山东大学学报（医学版）, 2015, 53(5): 81-84.

SUN Zhuohao, LIU Yan, ZHOU Dongmei, LI Wei. A clinic research of amitriptyline in treatment of painful diabetic peripheral neuropathy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 81-84.

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阿米替林治疗痛性糖尿病周围神经病变的临床研究

A clinic research of amitriptyline in treatment of painful diabetic peripheral neuropathy

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