非心源性疾病患者血清CK-MB增高原因探讨

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (Z1): 144-145.

非心源性疾病患者血清CK-MB增高原因探讨

董永康, 张恒

宜兴市人民医院检验科, 江苏宜兴 214200

收稿日期:2014-11-30 出版日期:2014-12-30 发布日期:2014-12-30

Study on increase of CK-MB level in patients with non-cardiac disease

DONG Yong-kang, ZHANG Heng

Department of Laboratory, Yixing People's Hospital, Yixing 214200, Jiangsu, China

Received:2014-11-30 Online:2014-12-30 Published:2014-12-30

摘要/Abstract

摘要： 目的探讨免疫抑制法检测非心源性疾病患者血清肌酸激酶同工酶(CK-MB)增高的原因与疾病的关系。方法回顾性分析干化学分析仪检测的CK正常但CK-MB异常升高者临床资料,进一步分析原因。结果 56例CK-MB异常升高的非心源性疾病患者中,儿童40例,肿瘤8例,脑损伤5例,3例为溶血标本;肿瘤和溶血标本中CK-MB/CK较高,分别为55.9%和54.2%。结论免疫抑制法检测非心源性疾病患者血清CK-MB时,可引起CK-MB假性增高。

关键词: 免疫抑制, CK-MB, 非心源性

Abstract: Objective To investigate the reason of increased level of creatine kinase-MB ( CK-MB) in patients with non-cardiac disease. Methods Clinical data of patients with normal level of CK and increased level of CK-MB were retrospectively analyzed. Results Out of 56 serum specimens with abnormal increase of CK-MB, 40 cases were from children, 8 cases from patients with cancer, 5 cases from patients with brain injury, 3 cases were hemolysis specimens. The average ratio of CK-MB/CK was 55.9% and 54.2% in specimen of cancer patients and hemolysis specimens, respectively. Conclusion Enzyme inhibition immunoassy may case false increase in levels of CK-MB among patients with non-cardiac disease.

Key words: Inhibition immunoassay, CK-MB, Non-cardiac

中图分类号:

R446.6

董永康, 张恒. 非心源性疾病患者血清CK-MB增高原因探讨[J]. 山东大学学报（医学版）, 2014, 52(Z1): 144-145.

DONG Yong-kang, ZHANG Heng. Study on increase of CK-MB level in patients with non-cardiac disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(Z1): 144-145.

参考文献

[1] Dawie J,Chawla R,Worku Y,et al.Diagnosis of ischemic heart disease using CK-MB,troponin-I and ischemia modified albumin[J].Ethiopian Medical Journal,2011,49(1): 25-33.
[2] 龚国忠,何理华,黄刚,等.CK、CK-MB,hs-cTNT 与急性心肌梗死梗死面积的关系[J].实验与检验医学,2013,30(6): 533-534.
[3] 王彩云,田亚平.肌酸激酶—MB 假性升高原因及与疾病的关系研究[J].军事医学科学院院刊,2002,26(2): 119-120.
[4] 陈丽峰,马增煌,吴琴.心肌酶及其比值和肌钙蛋白的测定对儿童病毒性心肌炎诊断价值探讨[J].实用医技杂志,2006,13(21): 3765-3766.
[5] 吴凤丽,马晓光,孙玉珍,等.血清 CK-MB 活力假性增高原因分析及临床意义[J].中国实验诊断学,2007,11(8): 1041-1043.

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