喷昔洛韦微乳经皮渗透的研究

山东大学学报(医学版)

喷昔洛韦微乳经皮渗透的研究

祝伟伟¹,翟光喜¹,于爱华¹,宋智梅^1,2

1. 山东大学药学院药物制剂研究所, 济南 250012; 2. 济南大学化学院, 济南 250022

收稿日期:2007-11-03 修回日期:1900-01-01 出版日期:2008-03-16 发布日期:2008-03-16
通讯作者: 翟光喜

Percutaneous penetration of Penciclovir microemulsions in vitro and in vivo

ZHU Wei-wei¹,ZHAI Guang-xi¹, YU Ai-hua¹,SONG Zhi-mei^1,2

1. Institute of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;2. School of Chemistry, Jinan University, Jinan 250022, China

Received:2007-11-03 Revised:1900-01-01 Online:2008-03-16 Published:2008-03-16
Contact: ZHAI Guang-xi

摘要/Abstract

摘要： 目的研究喷昔洛韦微乳体内外的透皮能力。方法采用Franz扩散池进行体外经皮渗透试验,自制微乳给药装置进行体内经皮渗透试验,采用高效液相法测定皮肤接收液、表皮及真皮中的药物浓度,并与市售夫坦乳膏比较,考察微乳的透皮促进作用。结果体外试验结果表明,0.5％的微乳12h时的单位面积累积渗透量是1％夫坦乳膏的3.5倍;体内试验表明,从微乳透过表皮到达真皮层的药物浓度明显高于乳膏剂(P＜0.05)。结论与夫坦乳膏相比,微乳对喷昔洛韦的透皮有显著的促进作用。

Abstract: To investigate the ability of percutaneous penetration of penciclovir microemulsions. MethodsFranz diffusion cells were used in vitro permeation studies and a selfmade open container was used in vivo permeation according to the references. The concentration of penciclovir in the receptor solution、 epidermis and dermis was determined by HPLC and compared with that of the commercial futan cream. ResultsIn vitro the Qn of penciclovir of the microemulsions at 12 hours was 35 times higher than that of the futan creams, however in vivo the penciclovir concentration in the dermis was obviously higher following microemulsion application compared with that following the cream application. ConclusionThe trans-dermal delivery ability of penciclovir is significantly increased with microemulsions compared with the commercial futan cream.

Key words: Penciclovir, Microemulsions, Cutaneous drug administration

中图分类号:

R944.9

祝伟伟,翟光喜,于爱华,宋智梅,. 喷昔洛韦微乳经皮渗透的研究[J]. 山东大学学报(医学版), 2008, 46(3): 320-323.

ZHU Wei-wei,ZHAI Guang-xi,YU Ai-hua,SONG Zhi-mei,. Percutaneous penetration of Penciclovir microemulsions in vitro and in vivo[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(3): 320-323.

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