慢性ITP小鼠外周血IL11及其受体水平的研究

山东大学学报(医学版)

慢性ITP小鼠外周血IL11及
其受体水平的研究

牛婷婷¹，陈力军¹，黄丽华²，杜雪²，张孝卫²

（1. 山东大学附属省立医院小儿血液科，济南 250021； 2. 济南市卫生科技交流服务中心，山东济南 250001）

收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2009-04-16
通讯作者: 陈力军

IL11 and IL11 receptor levels in the blood of mice with
chronic idiopathic thrombocytopenic purpura

NIU Tingting¹，　CHEN Lijun¹，　HUANG Lihua²， DU Xue²，　ZHANG Xiaowei²

（1. Department of Pediatric Hematology, Affiliated Provincial Hospital of Shandong University， Jinan 250021， China;
2. Jinan Medical Science Research Institute， Jinan 250001， China）

Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16
Contact: CHEN Lijun

摘要/Abstract

摘要： 目的测定慢性特发性血小板减少性紫癜（CITP）小鼠外周血中IL11及其受体（IL11R）的水平，探讨CITP的发病机制，为ITP的治疗提供新的理论依据。方法BALA/C小鼠60只，随机分为对照组（20只）和CITP组（40只），通过腹腔注射豚鼠抗小鼠血小板血清（APS）的方法建立CITP模型。于造模第8?d分别采用ELISA、流式细胞术测定两组小鼠外周血中IL11及IL11R的水平。结果CITP小鼠外周血中IL11及IL11R平均水平均较对照组升高（P＜0.05）；其中有31只小鼠同时存在IL11及IL11R水平的升高，余9只小鼠仅存在IL11水平的升高，而IL11R水平降低。结论IL11及IL11R在CITP的发病机制中起一定作用，但它们发挥作用的原理及过程尚需进一步探讨。

关键词: 白细胞介素11, 受体,白细胞介素11, ,紫癜,血小板减少性,特发性

Abstract: To explore IL11 and IL11 receptor in the blood of mice with chronic idiopathic thrombocytopenic purpura(CITP) and to assess whether the absence of IL11 or the IL11 receptor will provide a new theory in the treatment of CITP． Methods60 BALB/C mice which were randomly divided into two groups (20 mice in the control group and 40 in the CITP group)． The model of CITP was induced using intraperitoneal APS injection． Levels of IL11 and IL11 receptors were determined using ELISA and flowcytometry at the 8th day． ResultsThe levels of IL11 and the IL11 receptor in the blood of group CITP were higher thatthose of group control (P＜0.05)． In 31 mice of the CITP group，both the level of IL11 and of the IL11 receptor in the blood were increased, while in the remaining 9 mice of the CITP group，the level of IL11 in the blood was increased but the level of the IL11 receptor was decreased． ConclusionIL11 may have a certain action in the mechanism of ITP．

Key words: Interleukin 11, IL11 receptor, Chronic idiopathic thrombocytopenic purpura

中图分类号:

R554.6

牛婷婷1 ，陈力军1 ，黄丽华2 ，杜雪2 ，张孝卫2
. 慢性ITP小鼠外周血IL11及
其受体水平的研究[J]. 山东大学学报(医学版), 2009, 47(04): 69-71.

NIU Tingting¹，　CHEN Lijun¹，　HUANG Lihua²， DU Xue²，　ZHANG Xiaowei²
. IL11 and IL11 receptor levels in the blood of mice with
chronic idiopathic thrombocytopenic purpura[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(04): 69-71.

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