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偏振光显微镜对诊断原发性气管支气管淀粉样变的价值并文献复习

应央央,马德东,肖伟   

  1. 山东大学齐鲁医院呼吸内科, 山东 济南 250012
  • 收稿日期:2013-07-10 出版日期:2014-04-10 发布日期:2014-04-10
  • 通讯作者: 肖伟 E-mail:xiaowei4226@163.com

Siginifcance of polarizing microscope for the diagnosis of primary tracheobronchial amyloidosis and literature review #br#

YING Yangyang, MA Dedong, XIAO Wei   

  1. Department of Respiratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2013-07-10 Online:2014-04-10 Published:2014-04-10

摘要: 目的  探讨偏振光显微镜在诊断原发性气管支气管淀粉样变(PTBA)的价值,以减少误诊。方法  在偏振光显微镜下观察13例刚果红阳性患者的病理切片,并对1987年以来国内公开发表的104例临床资料完整、病理结果  确定的PTBA病例进行总结和分析。结果  偏振光显微镜下13例刚果红染色阳性患者病理切片只有8例显示黄绿色双折光体。单纯以刚果红阳性作为诊断标准的假阳性率为39.5%,照此比例国内报道的104例病例中有近40例存在误诊可能。结论  只有刚果红染色和偏振光显微镜观察均为阳性时,才能诊断PTBA。

关键词: 假阳性, 误诊, 原发性气管支气管淀粉样变, 偏振光显微镜

Abstract: Objective  To explore the application of polarizing microscope in the diagnosis of tracheobronchial amyloidosis, in order to reduce the rate of misdiagnosis. Methods  A total of 13 pathological sections positive for Congo red were re-observed, and 104 cases reported since 1987 which had complete clinical data and implicit pathological Results   were analyzed. Results  Of the 13 pathological sections, 8 showed apple-green birefringence when viewed under polarizing microscope. If the diagnosis of amyloidosis was based on Congo red staining only, it would result in 39.5% false positive cases, which might indciate that 40 cases might be misdiagnosed among the 104 confirmed cases. Conclusion  Only when both Congo red staining and polarizing microscope show positive Results  ,  can we diagnose the case as PTBA.

Key words: Primary tracheobronchial amyloidosis, Polarizing microscope, Misdiagnosis, False positive; 

中图分类号: 

  • R562.1
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