普卢利沙星的吸附伏安特性及其应用

山东大学学报(医学版)

普卢利沙星的吸附伏安特性及其应用

祝保林, 高锦红, 李吉峰

(渭南师范学院化学化工系, 陕西渭南 714000)

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-01-16 发布日期:2009-01-16

Adsorptive voltammetric behavior of prulifloxacin and its application

ZHU Baolin, GAO Jinhong, LI Jifeng

(Department of Chemistry and Chemical Engineering, Weinan Teacher′s College, Weinan 714000, Shannxi, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-01-16 Published:2009-01-16

摘要/Abstract

摘要： 目的探讨普卢利沙星的吸附伏安特性。方法在03?mol·L-1KH2PO4Na2HPO4 (pH640)底液中,普卢利沙星(prulifloxacin,PLF)在汞电极上有一线性扫描还原峰,峰电位EP=-102?V(vsAg／AgCl),该峰具有明显的吸附性。结果吸附粒子为PLF中性分子,测得PLF在汞电极上的饱和吸附量Γs=401×10-11mol·cm-2,每个PLF分子所占电极面积为202?nm2,PLF在汞电极上的吸附符合Langmuir吸附等温式;测得吸附系数β=108×106,25?℃时的吸附自由能ΔGθ=-2914?kJ·mol-1,电极反应电子数n=2,不可逆体系动力学参量αna=101,表面电极反应速率常量ks=027?s-1。结论建立了吸附溶出伏安法测定PLF的最佳条件,方法的检出限为20×10-8mol·L-1。

关键词: 普卢利沙星, 吸附溶出伏安法, 电化学行为, 药物分析

Abstract: To explore the Adsorptive Voltammetric Behavior of Prulifloxacin. MethodsIn a supporting electrolyte of 03?mol·L-1KH2PO4NaH2PO4(pH64), a reduction peac of Prulifloxacin (PLF) with a potential of-102?V (vs Ag／AgCL) and adsorptive characteristics were observed by linear sweep voltammetry at the Hg electrode. ResultsThe adsorbed species were most probably the neutral molecules of PLF. The saturated adsorption amount of 401×10-11mol·cm-2 and an area occupied by each molecule of 202?nm2 at Hg electrode for PLF were obtained. On the surface of the hanging mercury drop electrode, the adsorption obeyed a langmuir adsorption isotherm. The adsorption coefficient β, the Gibbs energy of adsorption ΔGθ at 25?℃,　the number of electrons transferred n, the kinetic parameter of the irrepersible system αnα and the rate constant of surface electrode reaction ks　were 108×106,　-2914?KJ·mol-1,　2,101 and 027?s-1, respectively. ConclusionA method for PLF assay was proposed by adsorptive stripping voltammetry. The detection limit of the method is 20×10-8 mol·L-1 under the optimized conditions.

Key words: Prulifloxacin, Adsorptive stripping voltammetry, Electrochemical behavior, Pharmaceutical analysis

中图分类号:

O6571

祝保林, 高锦红, 李吉峰
. 普卢利沙星的吸附伏安特性及其应用[J]. 山东大学学报(医学版), 2009, 47(01): 98-102.

ZHU Baolin, GAO Jinhong, LI Jifeng
. Adsorptive voltammetric behavior of prulifloxacin and its application[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(01): 98-102.

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