JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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SUIXiao-hui,XUYi-gao,LILi-zhen,ZHANGDi,YUYuan.PENGJun   

  • Received:2005-09-09 Revised:1900-01-01 Online:2006-05-24 Published:2006-05-24
  • Contact: SUIXiao-hui

Abstract: o investigate the inhibition of the PHAinduced abnormal bone marrow T lymphocyte proliferation and activation by the CTLA4Ig fusion protein in vitro in patients with aplastic anemia (AA). Method: Flow cytometry and immunofluorescence were used to analyze the mononuclear cells from bone marrow of the aplastic anemia patients. Result: In contrast to the controls, the expressions of the CD3, CD25, CD25 on CD4+, CD8+ lymphocytes were statistically decreased(P＜0.05) in both serious and nonserious AA. Conclusion: The CTLA4Ig fusion protein can induce the T cell tolerance and inhibit the T cell abnormal proliferation and activation in patients with AA.

Key words: Anemia, aplastic, Tlymphocytes, cytotoxic, Immune tolerance

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