JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression and significance of TRAIL and its receptors DcR1 and DR4 in cervical cancer tissues

ZHANG Wen-feng, ZHU Lin， ZHANG Ping   

  1. Department of Gynecologic and Obstetrical, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2007-08-27 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: ZHU Lin

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Abstract: Objective To determine the expression of TNF-related apoptosis inducing ligand (TRAIL) and its receptor DcR1, DR4 in cervical cancer and normal cervical tissues. MethodEnvision immunohistochemical method was used to determine the expressions of TRAIL, DcR1 and DR4 in tissues of 43 cases of cervical cancer and 30 cases of normal cervical tissues. ResultsThe expressions of TRAIL, DcR1 and DR4 were found in the cell membrane and cytoplasm and the expressions of TRAIL and DcR1 in cervical carcinoma tissues were significantly lower than those in the normal cervical tissues, while the expression of DR4 was higher in the cervical carcinoma tissues than in the normal cervical tissues(P＜0.05). The positive expression of TRAIL, DcR1, and DR4 in cervical carcinoma tissues was not related to patient's age, stage, lymphoid node diversion. Conclusion TRAIL may be one of the markers of poor differentiation of carcinoma cells. Cervical carcinoma cell apoptosis might be easily induced by TRAIL because of the high expression of DR4 and the low expression of DcR1.

Key words: Cervical neoplasms, TRAIL, DcR1, DR4

CLC Number: 

  • R737.33
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