JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Heparin reverses hepatic fibrosis in rats

SHI Jun, HAO Jing-hua, XU Hong-wei, REN Wan-hua, ZHU Ju-ren, KONG Xiang-hui   

  1. Center for Liver Disease, Shandong Provincial Hospital, Jinan 250021, Shandong, China
  • Received:2006-02-26 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24
  • Contact: HAO Jing-hua

PDF (PC)

986

Abstract: Objective: To evaluate the effects of heparin on liver fibrosis. Methods: Rats had liver fibrosis induced by carbon tetrachloride. The cirrhotic rats were subjected to different dosages of heparin. All the rats were killed after eight weeks and the serum levels of hyaluronate, collagen type Ⅳ, laminin， precollagen type Ⅲ and TG-β1 were determined. HE and a reticular fiber staining were used, and the expression of TGF-β1 in liver tissues was measured by an immunohistochemistry. The collagen deposit at Disse space was observed with a scanning electron microscope. Results: The serum indexes of heparin preventive treatment group and two heparin treatment groups produced many significant differences in the cirrhotic rats. The result of collagen staining showed that heparin significantly inhibited fibrosis in rats. The serum concentrations of TGF-β1 in heparin groups were decreased significantly. The collagen in Disse space was less in heparin groups observed with a scanning electron microscope. Conclusion: Heparin has anti-fibrosis effects owing to the decrease of TGF-β1 level.

Key words: Liver, Fibrosis, Heparin, Transforming growth factor-β1, Rats, Wistar

CLC Number: 

  • Q95-33
[1] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[2] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[3] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[4] WANG Shao-Qing, LIU Yi-Hui, FU Ting-Ting, CHENG Jin-Yong, LIU Qiang. Classification of 31P MRS data for hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 42-46.
[5] DONG Ping, SHEN Haitao, QIAO Yaqin, LU Yan. Role of autophagy in the regulation of APAP liver injury and liver regeneration process [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 42-49.
[6] LYU Mingyue, SUN Hanchen, LUO Qingxin, XU Zhaoke, XU Ruize, ZHANG Shuo, YAN Luning, HU Xifeng, ZHAO Qingbo, ZHU Gaopei, XUE Fuzhong. Therapeutic effect of nifedipine and metoprolol on heart disease [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 1-10.
[7] JIA Ruoxi, LYU Li, LIU Hanyun, WU Yinping, LI Fengcai, ZHAO Zehua, WANG Kai, FAN Yuchen. Diagnostic value of blood cell count-related biomarkers in predicting 28-day mortality in acute-on-chronic hepatitis b liver failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 89-99.
[8] WAN Wenjing, GAO Shanshan. Application of low molecular weight heparin in reproductive field [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 117-124.
[9] WU Haihuan, WANG Longlong, ZHAO Li, ZHANG Bing, MU Yanan, ZHANG Ge, SUN Chunhua. Relationship between body composition and metabolic associated fatty liver disease: a cross-sectional analysis [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 19-25.
[10] SONG Yanwei, FU Zhenmei, XU Jingyi, MA Mingze, SUN Linlin. Furin regulates mitophagy and liver fibrosis progression through phosphatase and tensin homolog-long in mouse [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 59-68.
[11] CHEN Qian, QIU Yifan, CHEN Shilong, WANG Chao, DONG Liang, SUN Congcong. Adult cystic fibrosis: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 42-47.
[12] TIAN Lijun, SANG Yujie, SUN Yujing, HAN Bing, QIN Chengyong, QI Jianni. The predictive value of systemic immune-inflammation index for immune checkpoint inhibitor treatment-related adverse reactions in patients with primary liver cancer [J]. Journal of Shandong University (Health Sciences), 2024, 62(6): 48-53.
[13] YANG Xueyan, WU Yinping, LYU Li, ZHAO Zehua, MA Hangyu, LI Fengcai, WANG Kai, FAN Yuchen. Diagnostic value of dynamic changes of monocyte-to-lymphocyte ratio in acute-on-chronic hepatitis B liver failure [J]. Journal of Shandong University (Health Sciences), 2024, 62(3): 61-69.
[14] ZHAO Zihui, WANG Xuyang, ZHANG Peng, FANG Ningning, SHI Duanbo, YANG Fan, YANG Xiaomei, WU Jianbo. Rapid and accurate assessment of pulmonary hypertension in rats via diaphragmatic puncture method [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 20-28.
[15] LIU Huanjun, GUO Shuxia, SHI Ruiping, ZHANG Wenbang, ZHANG Xiaojuan. Multisystemic Langerhans cell histiocytosis in adults: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2024, 62(2): 83-89.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd