Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (1): 49-53.doi: 10.6040/j.issn.1671-7554.0.2019.973

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Impact of body mass index on pregnancy outcomes in artificial insemination by husband

SONG Haixia,YUAN Caixia,FAN Lingling   

  1. Department of Reproductive Medicine, Shanxi Provincial Peoples Hospital, Taiyuan 030012, Shanxi, China
  • Published:2022-09-27

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Abstract: Objective To explore the impact of body mass index(BMI)on pregnancy outcomes of artificial insemination by husband(AIH)in letrozole plus human menopausal gonadotropin(HMG)ovulation cycle. Methods The clinical data of 325 patients who received AIH with letrozole plus HMG ovulation cycle were retrospectively analyzed. According to BMI, the patients were divided into obese group(BMI≥25 kg/m2, n=133)and control group(BMI<25 kg/m2, n=192). The clinical baseline parameters and pregnancy outcomes of the two groups were compared, including age, infertility time, basal hormones, antral follicol count(AFC), days and dosage of gonadotropin(Gn), and pregnancy outcomes. In the obese group, 68 patients had polycystic ovary syndrome(PCOS)and 65 had not, while in the control group, 83 had PCOS and 109 had not. The correlation between PCOS and pregnancy outcomes was analyzed. Results The obese group had longer days and higher dosage of Gn than the control group(P<0.05), but lower biochemical pregnancy rate(23.3% vs 29.2%,P=0.242), and there was no significant difference after prolactin(PRL)and PCOS were adjusted(OR=0.671, 95%CI:0.399-1.13). The obese group had lower clinical pregnancy rate than the control group(17.3% vs 26.6%, P=0.052), but there was significant difference after PRL and PCOS were adjusted 山 东 大 学 学 报 (医 学 版)58卷1期 -宋海霞,等.体质量指数对夫精人工授精妊娠结局的影响 \=-(OR=0.528, 95%CI:0.301-0.928). The obese group had lower live birth rate than the control group(10.5% vs 24.5%, P=0.002), and there was significant difference after PRL and PCOS were adjusted(OR=0.331, 95%CI:0.172-0.637). The obese group had higher abortion rate than the control group(12.8% vs 4.7%, P=0.011), and there was significant difference after PRL and PCOS were adjusted(OR=2.82, 95%CI:1.2-6.627). Conclusion In AIH with letrozole plus HMG ovulation cycle, obese patients may acquire lower live birth rate than non-obese patients. Obese women with or without PCOS should control BMI by means of diet, sports or drug treatment to improve pregnancy rate.

Key words: Body mass index, Artificial insemination by husband, Polycystic ovary syndrome, Pregnancy outcome

CLC Number: 

  • R711.75
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