Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (1): 43-48.doi: 10.6040/j.issn.1671-7554.0.2019.810

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High live birth rate in women with hypogonadotropic hypogonadism after treatment of in vitro fertilization

FENG Zhenhua, LI Yuanmei, CUI Wenjuan, SI Rui, SHENG Yan, ZHAO Han   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250001, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To evaluate the outcomes of in vitro fertilization and embryo transfer(IVF-ET)in women with hypogonadotropic hypogonadism(HH). Methods The retrospective study involved 79 women with HH(HH group)who received first cycle IVF-ET during Mar. 2013 and Jan. 2017 in Center for Reproductive Medicline, Shandoug University, and 270 controls(control group)with matched age, body mass index(BMI), and normal ovarian reserve who received IVF-ET due to oviduct diseases. The outcomes of IVF-ET were compared between the two groups. Results There were no statistical differences in clinical pregnancy rate, live birth rate of fresh or frozen embryo transfer and cumulative pregnancy rate between the two groups. The early abortion rate of fresh embryo transfer(8.82% vs 10.66%), rate of ectopic pregnancy(0% vs 1.4%)and early abortion rate of frozen embryo transfer(0% vs 6.98%)were lower in HH group than in control group although no statistical significance was obtained due to limited number of samples. The HH group had more dosage of gonadotropin(Gn)［(4 163.61±1 798.98)IU vs(1872.55±759.19)IU, P<0.001］and longer Gn stimulation duration ［(14.28±2.80)d vs(11.11±1.90)d, P<0.001］ than the control group. After we adjusted the total dosage and medication time of Gn, serum HCG and other related factors, we obtained similar results. Conclusion Women with hypophysical dysfunction will get expected high live birth rate and cumulative pregnancy rate 山 东 大 学 学 报 (医 学 版)58卷1期 -冯振花,等.79例低促性腺激素性腺功能减退患者体外受精-胚胎移植结局分析 \=-after IVF-ET/FET treatment. Their clinical outcomes are comparable to those of young patients with good ovarian function.

Key words: Hypogonadotropic hypogonadism, In vitro fertilization, Cumulative pregnancy rate

CLC Number: 

  • R711.6
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