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Expression of soluble endoglin and sFlt-1 in peripheral blood of pre-eclampsia

XING Jing, CHEN Li-jun   

  1. Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University， Jinan 250012, China
  • Received:2008-03-06 Revised:1900-01-01 Online:2008-11-16 Published:2008-11-16
  • Contact: CHEN Li-jun

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Abstract: To investigate the expression and significance of serum soluble endoglin(sEng) and soluble fmslike tyrosine kinase-1 (sFlt-1) in pre-eclampsia. MethodsSerum levels of sEng 1 and sFlt-1 were determined by enzyme linked immunosorbent assay. ResultsThe serum level of sEng of the preeclampsia group (5.27±1.05)ng／mL was significantly higher than that of the controls ［(1.26±0.40)ng／mL，P＜0.01］, especially of early-onset severe pre-eclampsia. The serum level of sFlt1 of the preeclampsia group (391.14±70.25)pg／mL was significantly higher than that of the third trimester group (27.57±4.36)pg／mL, but sFlt-1 did not correlate with the most severe forms of the disease. ConclusionSerum levels of sEng and sFlt-1 are significantly increased in preeclampsia, and the serum level of sEng is even higher in severe pre-eclampsia patients.

Key words: Preeclampsia, Soluble endoglin, Soluble fms-like tyrosine kinase receptor 1, Angiogenic factor

CLC Number: 

  • R714．25
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