JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Correlations of Syk with pathology and angiogenesis of pancreatic adenocarcinoma

ZHANG Hong-yu1, FEI Li-ming2,　WANG Chang-liang3,　ZHAO Wen-hua3,　ZHANG Bo3, ZHOU Wu-yuan3, ZHONG Wei-xia3, LI Sheng3   

  1. 1. Qilu Hospital of Shandong University, Jinan 250012, China; 2. Yantaishan Hospital, Yantai 264001, Shandong, China；3. Shandong Tumor Hospital, Jinan 250117, China
  • Received:2008-07-04 Revised:1900-01-01 Online:2008-09-16 Published:2008-09-16
  • Contact: LI Sheng

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Abstract: To study the expression of Syk and its correlations with clinical pathology and angiogenesis in pancreatic adenocarcinoma (PAC). Methods Forty PAC, 9 chronic pancreatitis and 8 normal pancreatic tissues were collected. The expressions of Syk protein in these tissues were assayed by immunohistochemical staining, and also expressions of Syk mRNA in PAC were investigated by realtime PCR. MVD marked by CD34 was detected by morphometric analysis, and the relationship between MVD and clinical pathology of PAC was analyzed. ResultsThe positivity rate of Syk protein in PAC, chronic pancreatitis and normal pancreatic tissues was 27.5%, 77.8% and 100%, respectively. There were 29 samples with negative Syk protein, and among them the Syk levels had no relations to the cancer position, but had relations to the TNM classification, tumor differentiation and lymphotic metastasis（P＜0.05）. The MVD was higher in positive Syk proteins than in negative ones (P=0.000). ConclusionsThe expression of Syk in pancreatic cancer is significantly lower than that in chronic pancreatitis and normal pancreatic tissues and is related to the development of pancreatic cancer. MVD has significant relationship with differentiation and histology types of PAC.

Key words: Spleen tyrosine kinase, Angiogenesis, Pathology, Pancreatic neoplasms

CLC Number: 

  • R735.9
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