JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 74-78.doi: 10.6040/j.issn.1671-7554.0.2015.782

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Fetal cervical enlargement development between 16 and 42 weeks of gestational age: a postmortem MRI study

DONG Jinye1,2, LIN Xiangtao1,2, CAO Jinfeng3, WU Yong1, ZHAO Hui4, XIE Huihui1, XIAO Lianxiang2   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Magnetic Resonance Imaging, Shandong Medical Imaging Research Institute, Jinan 250021, Shandong, China;
    3. Department of Radiology, Central Hospital of Zibo, Zibo 255036, Shandong, China;
    4. Department of Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250022, Shandong, China
  • Received:2015-08-18 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To investigate the normal development of fetal cervical enlargement, its maximum cross-sectional area and its relative position at different gestational ages using postmortem MRI. Methods A total of 44 fetal specimens ranging from 16-42 gestational weeks were enrolled. Three-dimensional(3D)T2-weighted(WI)imaging and Sampling Perfection with Application-optimized Contrast using differenced flip Angle Evolution(T2W-SPC)of the cervical spine were performed and then images were reconstructed in the coronal, axial, and sagittal planes. The following lobular parameters were measured: (1) the relationship between maximum cross-sectional area of cervical enlargement and gestational age; (2) the relative position of cervical enlargement at different gestational ages; (3) the significant differences in cervical enlargement maximum cross-sectional section area between sexes. Results (1) There were significant linear relationships between the maximum cross-sectional area and gestational ages(cervical enlargement 山 东 大 学 学 报 (医 学 版)54卷5期 -董金叶,等.16~42周胎儿脊髓颈膨大发育的MRI分析 \=-maximum cross-sectional area=0.01×gestational age-0.12, R2=0.91, P<0.05); (2) The maximum section of fetal cervical enlargement was located in the center of C5/6 at 16-28 gestational weeks and in the center of C5-C5/6 at 29-42 gestational weeks. The relative position of the maximum cross-sectional area of fetal enlargement gradually increased over gestation; (3) There was no significant difference in cervical enlargement maximum cross-sectional section area between sexes. Conclusion High field MRI clearly shows the maximum cross-sectional area of cervical enlargement and its relative position over gestation. We have established an MRI image map and database of normal fetal cervical enlargement.

Key words: Cervical enlargement, Fetal specimen, Cervical nerve, Magnetic resonance imaging

CLC Number: 

  • R323.1
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