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Effect of the Naoshenkang on monoamine neurotransmitters in the brain tissue of diabetes mellitus rats

GENG Lei1, LIU De-shan1, HAO Yuan-yuan1, GUO Rui-chen1, WANG Xin-lu2, ZHANG Wei-dong3   

  1. 1. Department of Outpatient, Qilu Hospital of Shandong University, J
    inan 250012, China;2. Shandong University of Traditional Chinese Medicine, Jinan 250011, China;3. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 2    50062, China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
  • Contact: LIU De-shan

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Abstract:

Objective〓〖WTBZ〗To explore the effect of the traditional Chinese medicine, Naoshenkang on monoamine neurotransmitters in brain tissues of diabetes mellitus rats. 〖WTHZ〗Methods〓〖WTBZ〗The diabetic model of Wistar rats was duplicated with one streptozotocin intraperitoneal injection, and then the model were randomly divided into 2 groups: the model control group and the Naoshenkang-treatment group, and healthy rats served as the normal control group. The Naoshenkang-treatment group was lavaged with 600?mg/kg naoshenkang per day, and the model control and the normal control groups were given an equal dose of normal saline. On the sixth weekend, all rats were killed， and then levels of blood sugar and insulin were determined, also the monoamine neurotransmitters in the discrete brain areas were determined. 〖WTHZ〗Results〓〖WTBZ〗The levels of blood sugar and insulin of the Naoshenkang-treatmentgroup were significantly lower than those of the model group(P＜0.05), also the levels of
norepinephrine (NE) and dopamine (DA) were decreased while the level of 5-hydroxytryptamine (5-HT) was significantly increased in the Naoshenkang-treatment group. The level of monoamine neurotransmitters was significantly different between the Naoshenkang-treatment group and the model group(P＜0.05). 〖WTHZ〗Conclusion〓〖WTBZ〗The traditional Chinese medicine Naoshenkang can efficiently regulate the level of monoamine neurotransmitters in brain tissues of diabetes mellitus rats.

Key words: Naoshenkang, Diabetes mellitus, Monoamine neurotransmitter, Rats, inbred strains

CLC Number: 

  • R587.1
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