JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Inhibitory effects of lead-excretion glycan on genetoxic and reproduction toxicity induced by lead in mice

ZHAO Hui-juan, LIU Ping, ZHUO Jin-hua, FENG Guo-chang   

  1. Department of Chemistry and Microbacteria Detection, School of Public Health, Shandong University, Jinan 250012, China
  • Received:2007-09-11 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: LIU Ping

PDF (PC)

309

Abstract: To study the influence of lead-excretion glycan on micronuclei formation in bone marrow and peripheral blood polychromatic erythrocyte (PCE) and on sperm abnormalities induced by lead in mice. Methods The KM strain mice were randomly divided into the negative control group, the positive control group, the lead control group, the high dosage group, the middle dosage group, the low dosage group and the preventative group based on body weight. The mice were given lead acetate by intraperitoneal injection and treated with lead-excretion glycan by intragastric administration. Micronucleus tests and sperm aberration tests were used． Results The micronuclei formation in bone marrow and peripheral blood PCE of the high and middle dosage groups were significantly less than that of the lead control group（P＜0.05）. The sperm abnormality rate of the high and middle dosage groups and the preventative group was significantly lower than that of the lead control group（P＜0.001）. Conclusion Leadexcretion glycan can to some extent inhibit the increase of micronuclei formation in bone marrow and peripheral blood PCE and sperm abnormalities in leadexposed mice.

Key words: Lead-excretion glycan, Lead, Mouse, Sperm abnormalities, Micronuclei

CLC Number: 

  • R155.33
[1] YANG Xiao-Qian, JI Jing, LIU Na, GUO Dong-Mei, CUI Xi. Effect of FeCl3 and FeEDTA on inhibiting psoriasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 114-117.
[2] WANG Suwei, LIU Yigang, AN Yuqin, YUAN Shuhua, HAO Haiyan, DING Tingting. Health risk assessment of cadmium and lead in a certain county with multi-pathways from 2018 to 2022 [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 106-113.
[3] LIU Min, ZHANG Yuchao, MA Xiaoli, LIU Xinyu, SUN Lu, ZUO Dan, LIU Yuantao. Effects of orphan nuclear receptor NR4A1 on H2O2 induced injury of mouse renal podocytes [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 16-21.
[4] ZHANG Weiwei, HUA Fang, LIANG Chaoshuai, CHU Miaomiao, SUN Jiayi, FRANK Zaucke, XIN Wei. Thyroid stimulating hormone promotes chondrocyte differentiation via anti-inflammatory protein CTRP3 [J]. Journal of Shandong University (Health Sciences), 2022, 60(10): 1-8.
[5] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1-6.
[6] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15-23.
[7] CAI Qiujing, ZHANG Qian, HE Xuejia, SUN Wenli, GUO Aili, ZHANG Nan, ZHU Weiwei. Airway smooth muscle cells regulate IL-33 expression through TGF-β1/Smad3 signaling pathway to participate in asthma [J]. Journal of Shandong University (Health Sciences), 2020, 58(4): 78-83.
[8] WAN Xiuxia, SUN Xiuping, TONG Jingjie. Anticancer effect of chrysophanol on colorectal cancer [J]. Journal of Shandong University (Health Sciences), 2019, 57(5): 74-79.
[9] KAN Haidong, JIANG Yixuan, CHEN Renjie. Leading researches on meteorological factors and human health [J]. Journal of Shandong University (Health Sciences), 2018, 56(8): 7-13.
[10] SU Xiaohui, SUN Mingqi, ZHANG Meijie, FANG Li, LUO Dandan, CHEN Guoping, YU Chunxiao, GUAN Qingbo. Application of Suiplus semen analysis automatic detection system and manual counting using hemocytometer in mouse semen analysis [J]. Journal of Shandong University (Health Sciences), 2018, 56(6): 1-5.
[11] ZHU Lin, LI Weiwei, LIU Zhikai. Human stromal vascular fraction combined with adipose stem cells promotes the healing of radiation skin damage in nude mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 66-72.
[12] LI Hongzhi, SHEN Yongchao, LIU Jieting, ZHAO Xiaojin, CHU Yanhui, YUAN Xiaohuan. An 11β-HSD1 inhibitor improves insulin sensitivity in db/db mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 59-64.
[13] SHI Rui, SUN Pei, WANG Lulu, DING Lin, XIA Jin, WANG Yan, PANG Shuguang. Vitamin D and mecobalamin combined with mouse nerve growth factor for diabetic peripheral neuropathy: a clinical observation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 64-67.
[14] YIN Yanyan, ZHAO Linyuan, ZHANG Xiaohuan, HUANG Hui, SUN Beibei, LI Wenjie. Effects of EGCG on the expressions of hippocampal amyloid beta protein and neprilysin enzyme in C57BL/6 young mice exposed to lead [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 8-13.
[15] JIA Junwei, ZHOU Xueying, LI Qiuhong, YU Kai, ZHOU Guoyu, ZHOU Shengnian. Expression of Annexin A7 in brain tissue of pilocarpine-induced epilepsy mouse model [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 6-10.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd