JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of substance P and its receptor in hepatic immune injury induced by Concanavalin A in mice

ZHANG Hai-tao， YAN Ming， SHANG Nan， LIU Hui-min， ZHANG Yu-quan   

  1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2008-01-29 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: YAN Ming

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Abstract: Objective To investigate the role of substance P and neurogenic inflammation mediated by SP in hepatic immune injury induced by concanavalin A(Con A). MethodsHepatic immune injury in mice was established by injection with 20mg/kg Con A through the tail vein. A saline control group was established by injection with saline. Liver damage was assessed by histological evaluation; SP contents in liver homogenates of the two groups were determined by enzymelinked immunosorbent assay (ELISA), and neurokinin-1 receptor expression was determined by reverse transcription and PCR(RT-PCR). ResultsHepatic immune injury in mice was successfully established, and hepatocellular apoptosis and granulocyte infiltration were found in livers in the model group. SP contents in liver homogenates were significantly increased in the model group（P＜0.01）. Moreover, NK-1R mRNA expression in the model group was obviously higher than that in the control group （P＜0.05）. ConclusionSP and its receptor participate in the process of inflammatory liver injury induced by Con A and play an important role in induction and maintenance of inflammation.

Key words: Hepatitis, autoimmune, Con A, Substance P, Neurokinin-1 receptor, Neurogenic inflammation

CLC Number: 

  • R575
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