JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.028

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Association of serum CTRP9 and APN levels with acute coronary syndrome

LIU Tianjiao1, GUO Yuan2, LI Tingting2, ZHANG Jianning3, LI Jun1, ZHANG Peng1   

  1. 1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of ICU, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-01-13 Revised:2014-09-05 Online:2014-09-10 Published:2014-09-10
  • Contact: 郭媛。E-mail:guoyuan9092@163.com E-mail:guoyuan9092@163.com

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Abstract: Objective To investigate the association of serum C1q/tumor necrosis factor related protein 9 (CTRP9) and adiponectin (APN) with acute coronary syndrome (ACS) and severity of coronary artery stenosis, and the potential mechanism. Methods A total of 61 patients with coronary heart disease(CHD) confirmed by coronary angiography (CAG) were divided into unstable angina pectoris group(UAP group, n=18), acute myocardial infarction group(AMI group, n=18), and stable angina pectoris group(SAP group, n=25). Healthy subjects without stenosis were as a control group(CON group, n=26). The UAP and AMI groups were dedined as acute coronary syndrome group (ACS group); the UAP, AMI and SAP groups were defined as coronary heart disease group(CHD goup). The serum levels of CTRP9 and APN were determined by enzyme-linked immunosorbent assay. The serum levels of lipids indexes and fasting plasma glucose(FPG)were also determined. The correlations of CTRP9 and APN with ACS and severity of coronary artery stenosis were analyzed with Pearson correlation analysis and multiple regression analysis. Results In CHD group, APN level was significantly lower than that in control group (P<0.01). In ACS group, CTRP9 level was significantly lower than those in control group (P<0.01) and SAP group (P<0.05). APN level was significantly lower than that in control group (P<0.01). In AMI group, CTRP9 level was significantly lower than that in SAP group (P<0.01). The serum CTRP9 level was positively correlated with APN (r=0.742, P<0.01) and negative correlated with FPG (r=0.592, P<0.01). CTRP9 level was only positively correlated with HDL-C level (r=0.254, P<0.05) in CHD group. Serum CTRP9 and APN levels were negatively correlated with Gensini score (r=0.579 and 0.777, P<0.01). Conclusion CTRP9 and APN are associated with ACS and the severity of coronary artery stenosis. It can provide a more convenient predictive target for the diagnosis and assessment of ACS and the severity of coronary artery disease.

Key words: C1q/tumor necrosis factor related protein 9, Coronary heart disease, Adiponectin, Acute coronary syndrome

CLC Number: 

  • R541.4
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