Abstract: Objective To explore the expressions and significances of serum hepatic cancer-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) in patients with non-small cell lung cancer (NSCLC). Methods A total of 30 patients with NSCLC served as NSCLC group while other 30 patients with benign lung disease as benign lung disease group, and 30 healthy people as control group. Serum HDGF and VEGF levels were compared among the three groups and analyzed in NSCLC group for their relevant factors and relationship. Results Benign lung disease group was evidently higher in serum HDGF level and lower in VEGF level than control group (P<0.01), while NSCLC group was obviously higher than control group in both HDGF and VEGF levels (P<0.01). However, NSCLC group was markedly lower in HDGF level but higher in VEGF level than benign lung disease group (P<0.01). Serum HDGF and VEGF levels had no significant relationship with ages and genders in NSCLC group, but they had apparent association with smoking history, adeno-carcinoma, non- and low- differentiation, pathological stage and lymph node metastasis. Serum HDGF and VEGF levels were positively correlated(r=0.33, P<0.01). Conclusion Serum HDGF level has close association with clinical stages, and serum VEGF level is closely correlated with conditions of lymph nodes and clinical stages of lung cancers, so they are helpful in the diagnosis of NSCLC.

Key words: Hepatic cancer-derived growth factor, Serum, Vascular endothelial growth factor, Non-small cell lung cancer